Product nameAnti-SOX10 antibody
See all SOX10 primary antibodies
DescriptionRabbit polyclonal to SOX10
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Zebrafish
Recombinant full length protein corresponding to Zebrafish SOX10 aa 1-485.
MSAEEHSMSEVEMSPGVSDDGHSMSPGHSSGAPGGADSPLPGQQSQMSGI GDDGAGVSGGVSVKSDEEDDRFPIGIREAVSQVLNGYDWTLVPMPVRVNS GSKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLN ETDKRPFIEEAERLRKQHKKDYPEYKYQPRRRKNGKPGSSSEADAHSEGE VSHSQSHYKSLHLEVAHGGAAGSPLGDGHHPHATGQSHSPPTPPTTPKTE LQGGKSGEGKREGGASRSGLGVGADGSSASSSASGKPHIDFGNVDIGEIS HDVMANMEPFDVNEFDQYLPPNGHPQASATASAGSAAPSYTYGISSALAA ASGHSTAWLSKQQLPSQQHLGADGGKTQIKSETHFPGDTAASGSHVTYTP LTLPHYSSAFPSLASRAQFAEYAEHQASGSYYAHSSQTSGLYSAFSYMGP SQRPLYTAIPDPGSVPQSHSPTHWEQPVYTTLSRP
Database link: Q90XD1
- WB: Zebrafish tissue lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.03% Proclin
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityProtein G purified
Purification notesPurity >95%.
Our Abpromise guarantee covers the use of ab229693 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/5000. Predicted molecular weight: 73 kDa.|
FunctionTranscription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia.
Tissue specificityExpressed in fetal brain and in adult brain, heart, small intestine and colon.
Involvement in diseaseDefects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E) [MIM:611584]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.
Defects in SOX10 are a cause of Waardenburg syndrome type 4C (WS4C) [MIM:613266]; also known as Waardenburg-Shah syndrome. WS4C is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
Defects in SOX10 are a cause of Yemenite deaf-blind hypopigmentation syndrome (YDBHS) [MIM:601706]. YDBHS consists of cutaneous hypopigmented and hyperpigmented spots and patches, microcornea, coloboma and severe hearing loss. Another case observed in a girl with similar skin symptoms and hearing loss but without microcornea or coloboma is reported as a mild form of this syndrome.
Defects in SOX10 are the cause of peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease (PCWH) [MIM:609136]; also called neurologic variant of Waardenburg-Shah syndrome. PCWH is a rare, complex and more severe neurocristopathy that includes features of 4 distinct syndromes: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease.
Sequence similaritiesContains 1 HMG box DNA-binding domain.
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
- DOM antibody
- DOM antibody
- Dominant megacolon mouse human homolog of antibody
All lanes : Anti-SOX10 antibody (ab229693) at 1/500 dilution
Lane 1 : Zebrafish tissue lysate at 40 µg
Lane 2 : Zebrafish tissue lysate at 20 µg
Lane 3 : Zebrafish tissue lysate at 10 µg
Lane 4 : Zebrafish tissue lysate at 5 µg
All lanes : Goat anti-rabbit IgG at 1/50000 dilution
Predicted band size: 73 kDa
Observed band size: 73 kDa
ab229693 has not yet been referenced specifically in any publications.