Recombinant
RabMAb

Recombinant Anti-SOX2 antibody [SP76] - N-terminal, prediluted (ab101547)

Overview

  • Product name

    Anti-SOX2 antibody [SP76] - N-terminal, prediluted
    See all SOX2 primary antibodies
  • Description

    Rabbit monoclonal [SP76] to SOX2 - N-terminal, prediluted
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human SOX2 aa 1-100 (N terminal). The exact sequence is proprietary.
    Database link: P48431

  • Epitope

    N-terminus
  • Positive control

    • IHC-P: Human prostate, lung, lung squamous cell carcinoma, ovarian adenocarcinoma, prostate hyperplasia, prostate PIN, cervical squamous cell carcinoma, cerebellum, esophagus, esophagus squamous cell carcinoma, bladder, bladder transitional cell carcinoma, bronchus, cervix, fallopian tube, lung adenocarcinoma, prostate adenocarcinoma, skin, skin squamous cell carcinoma, spinal cord, stomach and stomach adenocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab101547 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1.

Ready to use.

Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.

Incubate primary antibody for 30 minutes at room temperature.

Target

  • Function

    Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
  • Involvement in disease

    Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
  • Sequence similarities

    Contains 1 HMG box DNA-binding domain.
  • Post-translational
    modifications

    Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • ANOP3 antibody
    • cb236 antibody
    • Delta EF2a antibody
    • lcc antibody
    • MCOPS3 antibody
    • MGC148683 antibody
    • MGC2413 antibody
    • RGD1565646 antibody
    • Sex determining region Y box 2 antibody
    • SOX 2 antibody
    • Sox2 antibody
    • SOX2_HUMAN antibody
    • SRY (sex determining region Y) box 2 antibody
    • SRY box containing gene 2 antibody
    • SRY related HMG box 2 antibody
    • SRY related HMG box gene 2 antibody
    • SRY-box 2 antibody
    • Transcription factor SOX 2 antibody
    • Transcription factor SOX-2 antibody
    • ysb antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human stomach adenocarcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human stomach tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human spinal cord tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human skin squamous cell carcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human skin tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human prostate adenocarcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human lung adenocarcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human fallopian tube tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human cervix tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human bronchus tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human bladder transitional cell carcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human bladder tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human esophagus squamous cell carcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human esophagus tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human cerebellum tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human cervical squamous cell carcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human prostate PIN tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human prostate hyperplasia tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human ovarian adenocarcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human lung squamous cell carcinoma tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human lung tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human prostate tissue stained for SOX2 with ab101547 in immunohistochemical analysis.

References

ab101547 has not yet been referenced specifically in any publications.

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