Sp-5,6-Dichloro-cBIMPS, cAMP-dependent protein kinase activator (ab145202)

Overview

  • Product name

    Sp-5,6-Dichloro-cBIMPS, cAMP-dependent protein kinase activator
  • Description

    Cell-permeable, potent, selective activator of cAMP-dependent protein kinase
  • Alternative names

    • Sp-5,6-DCl-cBiMPS
  • Biological description

    cAMP analog. Cell-permeable, potent activator of cAMP-dependent protein kinase (PKA; Ka = 30 nM); Selective for PKA over cGMP-dependent protein kinase (PKG; Ka = 10 µM). Not significantly hydrolyzed by type I, II or III phosphodiesterases.

  • Purity

    > 98%
  • CAS Number

    120912-54-1
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    419.20
  • Molecular formula

    C12H10NaN2O5PSCl2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Isono A  et al. Involvement of cAMP-dependent unique signaling cascades in the decrease of serine/threonine-phosphorylated proteins in boar sperm head. Theriogenology 85:1152-60 (2016). Read more (PubMed: 26747578) »
  • Genieser HG  et al. Derivatives of 1-beta-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimic the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'-phosphate (cGMP). Carbohydr Res 234:217-35 (1992). Read more (PubMed: 1334800) »
  • Sandberg M  et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J 279 ( Pt 2):521-7 (1991). Read more (PubMed: 1659381) »

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