Overview

  • Product name

  • Description

    Rabbit polyclonal to SP110
  • Host species

    Rabbit
  • Specificity

    This product recognizes isoforms b and c.
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 15 amino acid synthetic peptide derived from near the carboxy terminus of human SP110; (NP_004501.3, SP110 isoform b).

  • Positive control

    • Human brain tissue. HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab67220 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
WB
IHC-P
  • Application notes
    IHC-P: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 63 kDa (predicted molecular weight of isoform b 63kDa, for longest isoform: 79 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
    • Tissue specificity

      Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • Involvement in disease

      Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
    • Sequence similarities

      Contains 1 bromo domain.
      Contains 1 HSR domain.
      Contains 1 PHD-type zinc finger.
      Contains 1 SAND domain.
    • Post-translational
      modifications

      Phosphorylated (isoform 2).
    • Cellular localization

      Nucleus. Found in the nuclear body.
    • Information by UniProt
    • Database links

    • Alternative names

      • FLJ22835 antibody
      • IFI 41 antibody
      • IFI 75 antibody
      • IFI41 antibody
      • IFI75 antibody
      • Interferon induced protein 41 30kD antibody
      • Interferon induced protein 41 antibody
      • Interferon induced protein 41/75 antibody
      • Interferon induced protein 75 52kD antibody
      • Interferon induced protein 75 antibody
      • Interferon-induced protein 41/75 antibody
      • IPR 1 antibody
      • IPR1 antibody
      • Phosphoprotein 41 antibody
      • Phosphoprotein 75 antibody
      • SP 110 antibody
      • SP110 antibody
      • Sp110 nuclear body protein antibody
      • SP110_HUMAN antibody
      • Speckled 110 kDa antibody
      • Transcriptional coactivator Sp110 antibody
      • VODI antibody
      see all

    Images

    • Lane 1 : Anti-SP110 antibody (ab67220) at 0.5 µg/ml
      Lane 2 : Anti-SP110 antibody (ab67220) at 1 µg/ml
      Lane 3 : Anti-SP110 antibody (ab67220) at 2 µg/ml

      All lanes : HeLa cell lysate

      Lysates/proteins at 15 µg per lane.

      Predicted band size: 63 kDa
      Observed band size: 63 kDa

    •  ab67220 at 2.5µg/ml staining of SP110 in human brain tissue using IHC-P.
    • Immunofluorescence of IPR1 in Human Brain cells using ab67220 at 50 ug/ml.

    References

    ab67220 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Question
    Answer

    Thank you for your enquiry. This product, ab67220 can detect isoform b, and c. Meanwhile, ab67221 can detect isoforms a, b,c.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

    Sign up