Key features and details
- Rabbit polyclonal to SP110
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-SP110 antibody
See all SP110 primary antibodies
DescriptionRabbit polyclonal to SP110
SpecificityThis product recognizes isoforms a, b and c.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
A 16 amino acid synthetic peptide derived from near the amino terminus of human SP1101. (GenBank accession no. NP_004501, isoform b).
- SW480 cell lysate
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab67221 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 80-95 kDa (predicted molecular weight: 79 kDa).|
FunctionTranscription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Tissue specificityHighly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Involvement in diseaseDefects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
Sequence similaritiesContains 1 bromo domain.
Contains 1 HSR domain.
Contains 1 PHD-type zinc finger.
Contains 1 SAND domain.
modificationsPhosphorylated (isoform 2).
Cellular localizationNucleus. Found in the nuclear body.
- Information by UniProt
- FLJ22835 antibody
- IFI 41 antibody
- IFI 75 antibody
Lane 1 : Anti-SP110 antibody (ab67221) at 1 µg/ml
Lane 2 : Anti-SP110 antibody (ab67221) at 2 µg/ml
All lanes : SW480 cell lysate
Lysates/proteins at 15 µg per lane.
All lanes : Anti rabbit secondary antibody
Predicted band size: 79 kDa
Observed band size: 80-95 kDa why is the actual band size different from the predicted?
ab67221 has been referenced in 1 publication.
- Molzan M et al. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol Cell Biol 30:4698-711 (2010). PubMed: 20679480