Overview

  • Product name

    Anti-Spastin antibody [RM346]
    See all Spastin primary antibodies
  • Description

    Rabbit monoclonal [RM346] to Spastin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Spastin (N terminal).
    Database link: Q9UBP0

  • Positive control

    • IHC-P: Human brain and tonsil tissue. WB: HeLa cells transfected with control siRNA.

Properties

Applications

Our Abpromise guarantee covers the use of ab238311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500 - 1/1000.
WB 1/500 - 1/1000. Predicted molecular weight: 68 kDa.

Target

  • Relevance

    Spastin is thought have a role in microtubule dynamics through its function as a microtubule severing protein. It is localised to the centrosome of neuronal cells but is not found in glial cells. Mutation in the ATPase binding domain of spastin causes hereditary spastic paraplegias (HSP), a large group of clinically similar disorders. Mutant forms of spastin are generally found throughout the cytoplasm rather then within the nucleus.
  • Cellular localization

    Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane, Microtubule, Nucleus
  • Database links

  • Alternative names

    • ADPSP antibody
    • FSP 2 antibody
    • FSP2 antibody
    • KIAA1083 antibody
    • Spast antibody
    • spastic paraplegia 4 (autosomal dominant; spastin) antibody
    • Spastic paraplegia 4 antibody
    • spastin antibody
    • SPG 4 antibody
    • SPG4 antibody
    • SPG4 gene antibody
    see all

Images

  • All lanes : Anti-Spastin antibody [RM346] (ab238311) at 1/500 dilution

    Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) cells transfected with control siRNA
    Lane 2 : HeLa cells transfected with Spastin siRNA

    Predicted band size: 68 kDa

  • Formalin-fixed, paraffin-embedded human tonsil tissue stained for Spastin with ab238311 at a 1/1000 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human brain tissue stained for Spastin with ab238311 at a 1/1000 dilution in immunohistochemical analysis.

References

ab238311 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab238311.
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