Overview

  • Product name

    Spautin-1, USP10 and USP13 inhibitor
  • Description

    Cell-permeable USP10 and USP13 inhibitor
  • Biological description

    Cell-permeable USP10 and USP13 inhibitor. Blocks autophagy. Active in vivo.
  • Purity

    > 97%
  • CAS Number

    1262888-28-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Fluoro-N-(4-fluorobenzyl)quinazoline-4-amine
  • Molecular weight

    271.26
  • Molecular formula

    C15H11F2N3
  • PubChem identifier

    51037431
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mateo R  et al. Inhibition of cellular autophagy deranges dengue virion maturation. J Virol 87:1312-21 (2013). Read more (PubMed: 23175363) »
  • Solano JD  et al. The products of the reaction between 6-amine-1,3-dimethyl uracil and bis-chalcones induce cytotoxicity with massive vacuolation in HeLa cervical cancer cell line. Eur J Med Chem 60:350-9 (2013). Read more (PubMed: 23314048) »
  • Liu J  et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147:223-34 (2011). Read more (PubMed: 21962518) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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