SPDP crosslinker, Cysteine and primary amine reactive short chain crosslinker (ab145613)

Overview

  • Product name

    SPDP crosslinker, Cysteine and primary amine reactive short chain crosslinker
  • Description

    Cysteine and primary amine reactive short chain crosslinker
  • Biological description

    Cysteine and primary amine reactive short chain crosslinker. Induces amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
  • Purity

    > 90%
  • CAS Number

    68181-17-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2,5-Dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
  • Molecular weight

    312.36
  • Molecular formula

    C12H12N2O10
  • PubChem identifier

    100682
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ciano M  et al. Conformation-specific crosslinking of mitochondrial complex I. FEBS Lett 587:867-72 (2013). Read more (PubMed: 23454639) »
  • Ma G  et al. Anchoring of self-assembled plasmid DNA/anti-DNA antibody/cationic lipid micelles on bisphosphonate-modified stent for cardiovascular gene delivery. Int J Nanomedicine 8:1029-35 (2013). Read more (PubMed: 23687446) »
  • Khawli LA  et al. Improved tumor localization and radioimaging with chemically modified monoclonal antibodies. Cancer Biother Radiopharm 11:203-15 (1996). Read more (PubMed: 10851539) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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