Anti-Spectrin (alpha + beta) antibody [B12G3] (ab33426)


  • Product name
    Anti-Spectrin (alpha + beta) antibody [B12G3]
  • Description
    Mouse monoclonal [B12G3] to Spectrin (alpha + beta)
  • Host species
  • Tested applications
    Suitable for: ELISA, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Native beta spectrin.



Our Abpromise guarantee covers the use of ab33426 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IHC-Fr Use at an assay dependent concentration.


  • Relevance
    Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton by associating with the cytoplasmic surface of the membrane by attachment to ankyrin. The membrane skeleton influences several cellular properties such as cell shape, restriction of mobility of the integral membrane protein exposed at the cell surface and transmembrane movement of phospholipids and cholesterol and organization of organelles. Spectrin is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. Mutations in spectrin result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
  • Cellular localization
    Cytoplasmic; Plasma membrane; Cytoskeleton
  • Database links
  • Alternative names
    • Alpha I spectrin antibody
    • Beta I spectrin antibody
    • Beta spectrin antibody
    • EL2 antibody
    • EL3 antibody
    • Erythroid Alpha Spectrin antibody
    • HPP antibody
    • HS2 antibody
    • HSPTB1 antibody
    • Spec A antibody
    • Spec B antibody
    • Spectrin Alpha Chain antibody
    • Spectrin Beta Chain antibody
    • Spectrin beta chain erythrocyte antibody
    • Spectrin beta erythrocytic antibody
    • spectrin, alpha, erythrocytic 1 (elliptocytosis 2) antibody
    • SPH2 antibody
    • SPH3 antibody
    • SPNA1 antibody
    • SPNB1 antibody
    • SPTA antibody
    • SPTA1 antibody
    • SPTB1 antibody
    see all


ab33426 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you very much for sending the data over.

I am very happy to hear that the antibodies worked well for you! I am also very happy to see, that all the antibodies seem to provide the expected doublet band. For the ab11184 it is effectively ...

Read More

Thank you for your reply.

I am happy to hear that the antibodyprovides a signal after optimisation, even though it is not very strong. I do not know whether this activity is due to the vial, the batch or if it is intrinsec of the antibody its...

Read More

I hope you had a good weekend.

Did you already had the opportunity to retest this antibody?

Indeed, I am writing to inquire if the suggestions have helped to improve the results? I would be pleased to receive an update on how these ...

Read More

Thank you for taking time to complete our questionnaire. I am sorry that this antibody is not providing satisfactory results.

The details provided will enable us to investigate this case and will provide us with vital information for monitor...

Read More

Thank you for contacting us.

I am sorry to hear you are experiencing difficulties with one of our products. We take product complaints very seriously, and investigate every product that we feel may not be performing correctly.

I a...

Read More


Sign up