Anti-Spermine synthase antibody (ab101458)
Key features and details
- Rabbit polyclonal to Spermine synthase
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
-
Product name
Anti-Spermine synthase antibody
See all Spermine synthase primary antibodies -
Description
Rabbit polyclonal to Spermine synthase -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow -
Immunogen
Recombinant fragment corresponding to a region within amino acids 144-336 of Human Spermine synthase (AAH09898).
-
Positive control
- 293T, A431 and Jurkat whole cell lysates; Raji cell lysate
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab101458 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 41 kDa.
|
Notes |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 41 kDa. |
Target
-
Function
Required for normal viability, growth and fertility. -
Pathway
Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1. -
Involvement in disease
Defects in SMS are the cause of Snyder-Robinson syndrome (SRS) [MIM:309583]; also known as X-linked mental retardation Snyder-Robinson type. SRS is characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive. -
Sequence similarities
Belongs to the spermidine/spermine synthase family. -
Domain
Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity. - Information by UniProt
-
Database links
- Entrez Gene: 615950 Cow
- Entrez Gene: 6611 Human
- Entrez Gene: 20603 Mouse
- Entrez Gene: 671878 Mouse
- Entrez Gene: 363469 Rat
- Omim: 300105 Human
- SwissProt: Q3SZA5 Cow
- SwissProt: P52788 Human
see all -
Alternative names
- MRSR antibody
- SMS antibody
- Snyder Robinson X linked mental retardation syndrome antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab101458 has not yet been referenced specifically in any publications.