Overview

  • Product name

    Anti-Spermine synthase antibody
    See all Spermine synthase primary antibodies
  • Description

    Rabbit polyclonal to Spermine synthase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Spermine synthase aa 16-191.
    Database link: P52788

  • Positive control

    • IHC-P: Human ovarian and prostate cancer tissues. ICC/IF: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab222836 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.
IHC-P 1/20 - 1/200.

Target

  • Function

    Required for normal viability, growth and fertility.
  • Pathway

    Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1.
  • Involvement in disease

    Defects in SMS are the cause of Snyder-Robinson syndrome (SRS) [MIM:309583]; also known as X-linked mental retardation Snyder-Robinson type. SRS is characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.
  • Sequence similarities

    Belongs to the spermidine/spermine synthase family.
  • Domain

    Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity.
  • Information by UniProt
  • Database links

  • Alternative names

    • MRSR antibody
    • SMS antibody
    • Snyder Robinson X linked mental retardation syndrome antibody
    • Spermidine aminopropyltransferase antibody
    • Spermine synthase antibody
    • SPMSY antibody
    • SpS antibody
    • SPSY_HUMAN antibody
    • SRS antibody
    see all

Images

  • HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for Spermine synthase (green) using ab222836 at 1/100 dilution in ICC/IF. Alexa Fluor 488-conjugated Goat anti-Rabbit IgG (H+L) was used as secondary antibody.

  • Paraffin-embedded human prostate cancer tissue stained for Spermine synthase using ab222836 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human ovarian cancer tissue stained for Spermine synthase using ab222836 at 1/100 dilution in immunohistochemical analysis.

References

ab222836 has not yet been referenced specifically in any publications.

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