Key features and details
- Rabbit polyclonal to SPG3A/ATL1
- Suitable for: ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-SPG3A/ATL1 antibody
See all SPG3A/ATL1 primary antibodies
DescriptionRabbit polyclonal to SPG3A/ATL1
ab196573 detects endogenous level of total SPG3A/ATL1 protein.
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Recombinant fragment corresponding to Human SPG3A/ATL1 (N terminal).
Database link: Q8WXF7
- WB: SH-SYSY, LOVO, H460, 293T, U87 and U251 cell lysates and mouse brain tissues lysate. ICC/IF: A549 cells.
This product was previously labelled as SPG3A
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.87% Sodium chloride
PBS is without Mg2+ and Ca2+.
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab196573 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||1/50 - 1/200.|
FunctionGTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.
Tissue specificityExpressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).
Involvement in diseaseDefects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3) [MIM:182600]; also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
Sequence similaritiesBelongs to the GBP family. Atlastin subfamily.
Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus membrane. Cell projection > axon.
- Information by UniProt
- AD FSP antibody
- atl1 antibody
- ATLA1_HUMAN antibody
ab196573 has not yet been referenced specifically in any publications.