Overview

  • Product name

  • Description

    Rabbit polyclonal to Spic
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ELISA, WBmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    A region within synthetic peptide: MTCCIDQDSL GQTFQDAIDI LIQQSAGESQ YSSENRNYMA IINPYPHVRG, corresponding to N terminal amino acids 1-50 of Mouse Spic

  • Positive control

    • SP2/0 lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab49112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/312500.
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 28 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
  • Tissue specificity

    Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.
  • Sequence similarities

    Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • AU019198 antibody
    • C76795 antibody
    • MGC40611 antibody
    • MGC80555 antibody
    • Prf antibody
    • Pu.1 related factor antibody
    • Spi C antibody
    • Spi C transcription factor antibody
    • Spi-C transcription factor (Spi-1/PU.1 related) antibody
    • spiC antibody
    • SPIC_HUMAN antibody
    • Transcription factor Spi-C antibody
    see all

Images

References

ab49112 has not yet been referenced specifically in any publications.

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