Overview

  • Product name

    Spiramycin (Rovamycine), Macrolide antibiotic
  • Description

    Macrolide antibiotic
  • Biological description

    Macrolide antibiotic. Inhibits bacterial translocation of protein synthesis.
  • CAS Number

    8025-81-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[5-(4,5-Dihydroxy-4,6-dimethyloxan-2-yl)oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde (for Spiramycin I, R=H)
  • Molecular weight

    843.05
  • Molecular formula

    C43H74N2O14 (for Spiramycin I, R=H)
  • PubChem identifier

    6419898
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)OC4CCC(C(O4)C)N(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chew WK  et al. Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis. Antimicrob Agents Chemother 56:1762-8 (2012). Read more (PubMed: 22271863) »
  • Wang J & Leung D Determination of spiramycin and neospiramycin antibiotic residues in raw milk using LC/ESI-MS/MS and solid-phase extraction. J Sep Sci 32:681-8 (2009). Read more (PubMed: 19165836) »
  • Smith CR The spiramycin paradox. J Antimicrob Chemother 22 Suppl B:141-4 (1988). Read more (PubMed: 3053567) »

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