Spironolactone, Mineralocorticoid receptor antagonist (ab141289)
- Datasheet
- References
Overview
-
Product name
Spironolactone, Mineralocorticoid receptor antagonist -
Description
Mineralocorticoid receptor antagonist -
Alternative names
- SC 9420
-
Biological description
Mineralocorticoid receptor antagonist (IC50 values are 24 and 77 nM at mineralocorticoid and androgen receptors respectively). Inhibits aldosterone binding to Mineralocorticoid receptor. Prevents sodium reabsorption. Active in vivo. -
Purity
> 99% -
CAS Number
52-01-7 -
Chemical structure
Properties
-
Chemical name
(7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid-γ-lactone -
Molecular weight
416.57 -
Molecular formula
C24H32O4S -
PubChem identifier
5833 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(=O)S[C@@H]4CC1=CC(=O)CC[C@]1(C)[C@H]5CC[C@@]3(C)[C@@H](CC[C@]23CCC(=O)O2)[C@H]45 -
Source
Synthetic
-
Research areas
References
This product has been referenced in:
- Luo W et al. Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO/PKG pathway in the bile-duct-ligated rat. PLoS One 7:e34230 (2012). Read more (PubMed: 22479572) »
- Fagart J et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem 285:29932-40 (2010). Read more (PubMed: 20650892) »
- Ye P et al. Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm Metab Res 41:35-9 (2009). Read more (PubMed: 18819053) »
