Spironolactone, Mineralocorticoid receptor antagonist (ab141289)
Key features and details
- Mineralocorticoid receptor antagonist
- CAS Number: 52-01-7
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Spironolactone, Mineralocorticoid receptor antagonist -
Description
Mineralocorticoid receptor antagonist -
Alternative names
- SC 9420
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Biological description
Mineralocorticoid receptor antagonist (IC50 values are 24 and 77 nM at mineralocorticoid and androgen receptors respectively). Inhibits aldosterone binding to Mineralocorticoid receptor. Prevents sodium reabsorption. Active in vivo.
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Purity
> 99% -
CAS Number
52-01-7 -
Chemical structure
Properties
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Chemical name
(7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid-γ-lactone -
Molecular weight
416.57 -
Molecular formula
C24H32O4S -
PubChem identifier
5833 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)S[C@@H]4CC1=CC(=O)CC[C@]1(C)[C@H]5CC[C@@]3(C)[C@@H](CC[C@]23CCC(=O)O2)[C@H]45 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
Images
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Chemical Structure - Spironolactone, Mineralocorticoid receptor antagonist (ab141289)2D chemical structure image of ab141289, Spironolactone, Mineralocorticoid receptor antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab141289 has been referenced in 1 publication.
- Zhang B et al. Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling. J Neuroinflammation 17:318 (2020). PubMed: 33100225