Anti-spn-E antibody (ab5204)

This fast track antibody is not yet fully characterized. It is subject to these terms and conditions.

Overview

  • Product name

    Anti-spn-E antibody
  • Description

    Rabbit polyclonal to spn-E

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species

    Rabbit
  • Species reactivity


    Predicted to work with: Drosophila melanogaster
  • Immunogen

    Synthetic peptide corresponding to Drosophila melanogaster spn-E aa 1400-1500 conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab23611)

  • General notes

    Tested in peptide ELISA.

     This product was previously labelled as Spindle E

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Target

  • Function

    Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis.
  • Sequence similarities

    Belongs to the DEAD box helicase family. DEAH subfamily.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
    Contains 1 Tudor domain.
  • Cellular localization

    Cytoplasm. Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis.
  • Information by UniProt
  • Database links

    • Alternative names

      • CG3158 antibody
      • CG3158 PA antibody
      • female sterile(3)homeless antibody
      • Fs(1)hls antibody
      • Hls antibody
      • Homeless antibody
      • Probable ATP-dependent RNA helicase spindle-E antibody
      • Spindle E CG3158 PA antibody
      • SpindleE antibody
      • Spn E antibody
      • Spn E/hls antibody
      • spn-E antibody
      • SpnE antibody
      • SPNE_DROME antibody
      see all

    References

    ab5204 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Answer

    Thank you for your enquiry. Spindle-E is part of the RNA interference machinery and therefore a nuclear protein. You may wish to consult the reference: Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. 2004. Pal-Bhadra M, Leibovitch BA, Gandhi SG, Rao M, Bhadra U, Birchler JA, Elgin SC. Science. 30;303(5658):669-72. I hope this information helps, please do not hesitate to contact me should you require further assistance.

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