Overview

  • Product name

    Anti-SPTBN2 antibody [SPTBN2/1778]
    See all SPTBN2 primary antibodies
  • Description

    Mouse monoclonal [SPTBN2/1778] to SPTBN2
  • Host species

    Mouse
  • Tested applications

    Suitable for: Protein Array, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human SPTBN2 aa 356-475. The exact sequence is proprietary.
    Database link: O15020

  • Positive control

    • IHC-P: Human pancreas tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab238055 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Protein Array Use at an assay dependent concentration.
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Incubate with primary ab for 30 minutes at RT

Target

  • Relevance

    SPTBN2 (Spectrin beta non erythrocytic 2) probably plays an important role in neuronal membrane skeleton. It is highly expressed in Purkinje cells and stabilizes the glutamate transporter EAAT4 at the surface of the plasma membrane.
  • Cellular localization

    Cytoplasmic
  • Database links

  • Alternative names

    • Beta III spectrin antibody
    • Glutamate transporter EAAT4 associated protein 41 antibody
    • GTRAP41 antibody
    • SCA 5 antibody
    • SCA5 antibody
    • SCAR14 antibody
    • Spectrin beta chain brain 2 antibody
    • Spectrin beta III sigma 2 antibody
    • Spectrin beta non erythrocytic 2 antibody
    • Spectrin non erythroid beta chain 2 antibody
    • Spinocerebellar ataxia 5 antibody
    • Spinocerebellar ataxia 5 protein antibody
    • SPTBN 2 antibody
    see all

Images

  • ab238055 was tested in protein array against over 19000 different full-length human proteins.
    Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
    A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
  • Formalin-fixed, paraffin-embedded human pancreas tissue stained for SPTBN2 using ab238055 at 2 μg/mL in immunohistochemical analysis.

References

ab238055 has not yet been referenced specifically in any publications.

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