Overview

  • Product name

    SQ 22536, Non-competitive adenylyl cyclase inhibitor
  • Description

    Non-competitive adenylyl cyclase inhibitor
  • Biological description

    Non-competitive adenylyl cyclase inhibitor. Inhibits catecholamine stimulated cAMP production (IC50 values are 0.08-1.45 and 0.08-0.27 mM in catfish and rat hepatocyte cell membranes, respectively). Inhibits muscarinic Ca2+ signalling in rat carotid bodies in vitro.
  • Purity

    > 99%
  • General notes

    This compound appears to be unstable in strongly acidic solutions. We therefore recommend avoiding exposure to low pH.

  • CAS Number

    17318-31-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Thompson CM & Wyatt CN Inhibition of adenylate cyclase attenuates muscarinic Ca²(+) signaling by a PKA-independent mechanism in rat carotid body Type I cells. Respir Physiol Neurobiol 175:90-6 (2011). Read more (PubMed: 20870042) »
  • Fabbri E  et al. Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J Enzyme Inhib 5:87-98 (1991). Read more (PubMed: 1669444) »

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