Overview

  • Product name

    SR-12813, PXR agonist
  • Description

    Potent, selective PXR agonist
  • Biological description

    Potent, selective PXR agonist. (EC50 = 200 nM for human PXR). Inhibits cholesterol biosynthesis. Cell permeable. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    126411-39-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sever N  et al. Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 279:43136-47 (2004). Read more (PubMed: 15247248) »
  • Ness GC & Chambers CM Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity. Proc Soc Exp Biol Med 224:8-19 (2000). Read more (PubMed: 10782041) »
  • Berkhout TA  et al. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 271:14376-82 (1996). Read more (PubMed: 8662919) »

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