Overview

  • Product name

    SR 3576, JNK3 inhibitor
  • Description

    Potent, selective JNK3 inhibitor
  • Biological description

    Potent, selective JNK3 inhibitor (IC50 values are 7 nM and 20 μM for JNK3 and p38, respectively).
  • Purity

    > 98%
  • CAS Number

    1164153-22-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide
  • Molecular weight

    501.54
  • Molecular formula

    C27H27N5O5
  • PubChem identifier

    70702008
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=CC=C1)NC(=O)NC2=CN(N=C2)C3=CC=CC(=C3)C(=O)NC4=CC(=C(C(=C4)OC)OC)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bolam JP  et al. Synaptic input and local output of dopaminergic neurons in grafts that functionally reinnervate the host neostriatum. Exp Brain Res 68:131-46 (1987). Read more (PubMed: 2446902) »

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