Overview

  • Product name

    SR95531 (Gabazine) (mM/ml), GABAA antagonist
  • Description

    GABAA antagonist. 1 ml water soluble pack.
  • Alternative names

    • Gabazine
  • Biological description

    Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity

    > 98%
  • CAS Number

    104104-50-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide
  • Molecular weight

    368.23
  • Molecular formula

    C15H17N3O3.HBr
  • PubChem identifier

    107895
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml of water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [Br-].COc1ccc(cc1)C=2C=CC(=[NH2+])N(CCCC(=O)O)N=2
  • Source

    Synthetic

  • Research areas

Images

  • Increased tonic GABA currents and altered IPSC properties in TC neurons of SSADH−/− mice.

    C, representative current traces from thalamocortical neurons of WT (left) and SSADH−/− (right) mice showing the difference in tonic current amplitude between the two genotypes. Dotted lines represent the initial baseline current prior to the focal application of 50 µM GBZ (white bar).

    GBZ = Gabazine.

    (From Figure 1 of Erringtom et al).

References

This product has been referenced in:

  • Ueno S  et al. Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. J Neurosci 17:625-34 (1997). Read more (PubMed: 8987785) »
  • Ito Y  et al. Characterization of antagonistic activity and binding properties of SR 95531, a pyridazinyl-GABA derivative, in rat brain and cultured cerebellar neuronal cells. Synapse 10:326-33 (1992). Read more (PubMed: 1585261) »
  • Wermuth CG  et al. Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of gamma-aminobutyric acid acting as selective GABA-A antagonists. J Med Chem 30:239-49 (1987). Read more (PubMed: 3027337) »
See all 54 Publications for this product

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