Overview

  • Product name

  • Description

    Rabbit polyclonal to SRAP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SRAP (internal sequence) conjugated to keyhole limpet haemocyanin.
    Database link: Q9HD15

  • Positive control

    • IHC-P: Human skeletal muscle and liver tissues. WB: HEK-293T, NS-1 and PC-12 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab230510 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 26 kDa.
IHC-P 1/100.

Target

  • Function

    Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
  • Tissue specificity

    Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.
  • Sequence similarities

    Belongs to the SRA1 family.
  • Cellular localization

    Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • MGC87674 antibody
    • PP7684 antibody
    • SR A1 antibody
    • SRA antibody
    • SRA1 antibody
    • SRA1_HUMAN antibody
    • SRAP antibody
    • Steroid receptor coactivator antibody
    • Steroid receptor RNA activator 1 (complexes with NCOA1) antibody
    • Steroid receptor RNA activator 1 antibody
    • Steroid receptor RNA activator protein antibody
    • STRAA1 antibody
    see all

Images

  • All lanes : Anti-SRAP antibody (ab230510) at 1/500 dilution

    Lane 1 : HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate
    Lane 2 : NS-1 cell lysate
    Lane 3 : PC-12 (Rat adrenal gland pheochromocytoma cell line) cell lysate

    Predicted band size: 26 kDa

  • Formalin-fixed, paraffin-embedded human liver tissue stained for SRAP using ab230510 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human skeletal muscle tissue stained for SRAP using ab230510 at 1/100 dilution in immunohistochemical analysis.

References

ab230510 has not yet been referenced specifically in any publications.

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