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Inquiry: Hi Abcam I don't have a problem with this product but I need some info on it: please can you find out if this antibody detects pLyn(396) ONLY, or does it detect phosphorylation of any other src family member site? thankyou for your help
Asked on Mar 06 2013
Thank you for your enquiry regarding ab40660.
Based on the sequence homology, it is unlikely that this antibody would cross react with the other tyrosines of Lyn. However, it might cross-react with LCK, HCK and possibly Src when phosphorylated at equivalent sites since Lyn shares high sequence homology with other Src family members.
Please note that the development of all phospho-specific antibodies requires to screen on phospho specific peptide and counter-screen on its corresponding non-phospho specific control peptide.
If you need any further assistance in the future, please do not hesitate to contact me.
Answered on Mar 06 2013