Product nameSREBP2 peptide
See all SREBP2 proteins and peptides
Our Abpromise guarantee covers the use of ab174740 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-SREBP2 antibody (ab30682)
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Preparation and Storage
Stability and Storage
Store at -20°C.
Information available upon request.
- Class D basic helix-loop-helix protein 2
FunctionTranscriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Tissue specificityUbiquitously expressed in adult and fetal tissues.
Sequence similaritiesBelongs to the SREBP family.
Contains 1 basic helix-loop-helix (bHLH) domain.
modificationsAt low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
Cellular localizationNucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle > COPII-coated vesicle membrane. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
- Information by UniProt
ab174740 has not yet been referenced specifically in any publications.