Key features and details
- Rabbit polyclonal to SRGAP1
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SRGAP1 antibody
See all SRGAP1 primary antibodies
DescriptionRabbit polyclonal to SRGAP1
Tested applicationsSuitable for: IPmore details
Unsuitable for: WB
Species reactivityReacts with: Human
Predicted to work with: Cow, Pig, Rhesus monkey, Gorilla, Orangutan
Synthetic peptide corresponding to a region between residue 825 and 875 of human SRGAP1 (NP_065813.1)
- HeLa whole cell lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab75281 was affinity purified using an epitope specific to SRGAP1 immobilized on solid support.
Our Abpromise guarantee covers the use of ab75281 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at 2-5 µg/mg of lysate.|
FunctionGTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Tissue specificityExpressed in brain, lung, kidney, and testis.
Sequence similaritiesContains 1 FCH domain.
Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.
DomainThe F-BAR domain mediates oligomerization, binds membranes, and constrains plasma membrane protrusions.
- Information by UniProt
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ab75281 has not yet been referenced specifically in any publications.