Overview

  • Product name
    Anti-SRRM4 antibody
  • Description
    Rabbit polyclonal to SRRM4
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 270-319 (KTASPLTTSR GRSQEYDSGN DTSSPPSTQT SSARSRGQEK GSPSGGLSKS) of Human SRRM4 (NP_919262).

  • Positive control
    • Human Fetal Liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab112092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 69 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts.
  • Tissue specificity
    Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.
  • Sequence similarities
    Belongs to the nSR100 family.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1500001A10Rik antibody
    • B230202K19Rik antibody
    • KIAA1853 antibody
    • Medulloblastoma antigen MU-MB-2.76 antibody
    • mKIAA1853 antibody
    • Neural-specific serine/arginine repetitive splicing factor of 100 kDa antibody
    • Neural-specific SR-related protein of 100 kDa antibody
    • nSR100 antibody
    • RGD1560213 antibody
    • Serine/arginine repetitive matrix protein 4 antibody
    • Srrm4 antibody
    • SRRM4_HUMAN antibody
    see all

Images

  • Anti-SRRM4 antibody (ab112092) at 1 µg/ml + Human Fetal Liver lysate at 10 µg

    Predicted band size: 69 kDa

References

ab112092 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for contacting Abcam.

I have talked to the lab about your questions and please find their response below:

Based on the reviewed UniProt entry for this gene (http://www.uniprot.org/uniprot/A7MD48), it is predicted to have a MW of 68kD. Of course, the actual MW may be of a slightly different size. As for the sample type, thanks for bringing this to our attention. I will have this antibody reQC’d with a more appropriate tissue. If the reQC result is favorable, we will immediately update our product page.

Please let me know if you have additional questions and I will definitely pass your information along to our team that is in charge of setting collaborations. Also we do guarantee the antibody to work as stated on the datasheet and if you were to have any issues with it if you purchased it, then we would be happy to either replace or refund the cost of the antibody.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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