Overview

  • Product name

  • Description

    Rabbit polyclonal to SS18
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SS18. Surrounding amino acid Ala7.
    Database link: Q15532

  • Positive control

    • HepG2 cell extract; Human Lung endothelium tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab179927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 42 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
  • Tissue specificity

    Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
  • Involvement in disease

    Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • Sequence similarities

    Belongs to the SS18 family.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • MGC116875 antibody
    • Protein SSXT antibody
    • Protein SYT antibody
    • SS18 antibody
    • SSXT antibody
    • SSXT/SSX4v fusion antibody
    • SSXT_HUMAN antibody
    • Synovial sarcoma translocated to X chromosome antibody
    • Synovial sarcoma translocated to X chromosome protein antibody
    • Synovial sarcoma translocation chromosome 18 antibody
    • SYT antibody
    • SYT SSX1 antibody
    • SYT SSX2 antibody
    • SYT/SSX4v fusion protein antibody
    • SYTSSX1 antibody
    • SYTSSX2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin embedded Human lung epithelium tissue labeling SS18 with ab179927 at 5 µg/ml.

  • Anti-SS18 antibody (ab179927) at 1/500 dilution + HepG2 cell extract

    Predicted band size: 42 kDa

References

ab179927 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab179927.
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