Product nameSSR128129E, FGFR inhibitor
DescriptionSelective allosteric FGFR inhibitor. Potent antiproliferative agent.
Biological descriptionSelective allosteric FGFR inhibitor (IC50 = 1.9 μM, FGFR1). Potent antiproliferative agent. Potently inhibits FGF2-induced epithelial cell proliferation and migration (IC50 values are 31 and 15 nM respectively). Shows antiangiogenic, anti-inflammatory and antitumor effects in vivo. Orally active.
Chemical name2-Amino-5-(1-methoxy-2-methylindolizine-3-carbonyl)benzoate sodium salt
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Fons P et al. Tumor vasculature is regulated by FGF/FGFR signaling-mediated angiogenesis and bone marrow-derived cell recruitment: this mechanism is inhibited by SSR128129E, the first allosteric antagonist of FGFRs. J Cell Physiol 230:43-51 (2015). Read more (PubMed: 24760775) »
- Ader I et al. Preclinical evidence that SSR128129E--a novel small-molecule multi-fibroblast growth factor receptor blocker--radiosensitises human glioblastoma. Eur J Cancer 50:2351-9 (2014). Read more (PubMed: 24953334) »
- Dol-Gleizes F et al. A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient mice. PLoS One 8:e80027 (2013). Read more (PubMed: 24224032) »