Overview

  • Product name

  • Description

    Rabbit polyclonal to ST3GAL5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 174-418 of Human ST3GAL5 (Uniprot ID: Q9UNP4).

  • Positive control

    • A431, Jurkat, Raji and Mouse brain whole cell lysates; Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab155671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 48 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).
  • Tissue specificity

    Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.
  • Involvement in disease

    Defects in ST3GAL5 are the cause of Amish infantile epilepsy syndrome (AIES) [MIM:609056]. AIES is an autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness.
  • Sequence similarities

    Belongs to the glycosyltransferase 29 family.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 3-sialyltransferase antibody
    • CMP-NeuAc:lactosylceramide alpha-2 antibody
    • CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase antibody
    • EC 2.4.99.9 antibody
    • Ganglioside GM3 synthase antibody
    • Lactosylceramide alpha-2,3-sialyltransferase antibody
    • Sialyltransferase 9 antibody
    • SIAT9 antibody
    • SIAT9_HUMAN antibody
    • SIATGM3S antibody
    • ST3 beta-galactoside alpha-2,3-sialyltransferase 5 antibody
    • ST3GAL antibody
    • ST3Gal V antibody
    • ST3GAL5 antibody
    • ST3GalV antibody
    see all

Images

  • Anti-ST3GAL5 antibody (ab155671) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size: 48 kDa



    10% SDS PAGE
  • Anti-ST3GAL5 antibody (ab155671) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 48 kDa



    10% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labeling ST3GAL5 with ab155671 at 1/500 dilution.

References

This product has been referenced in:

  • Li Y  et al. Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1. Lab Invest 96:731-40 (2016). Read more (PubMed: 27088512) »
See 1 Publication for this product

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