Overview

  • Product name

    STA-21 (Ochromycinone), STAT3 inhibitor
  • Description

    Selective STAT3 inhibitor
  • Biological description

    Selective STAT3 inhibitor. Shows antiproliferative effects (IC50 values are 12.2 and 18.7 μM for DU145 and PC3 cell lines respectively). Shows anti-inflammatory effects in vivo.
  • Purity

    > 98%
  • CAS Number

    28882-53-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S)-8-Hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione
  • Molecular weight

    306.31
  • Molecular formula

    C19H14O4
  • PubChem identifier

    11808929
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Park JS  et al. STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. Arthritis Rheumatol 66:918-29 (2014). Read more (PubMed: 24757144) »
  • Furqan M  et al. STAT inhibitors for cancer therapy. J Hematol Oncol 6:90 (2013). Read more (PubMed: 24308725) »
  • Bhasin D  et al. Design, synthesis, and studies of small molecule STAT3 inhibitors. Bioorg Med Chem Lett 18:391-5 (2008). Read more (PubMed: 18006313) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145648.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up