Key features and details
- Rabbit polyclonal to Stabilin 2
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Stabilin 2 antibody
See all Stabilin 2 primary antibodies
DescriptionRabbit polyclonal to Stabilin 2
Tested applicationsSuitable for: IHC-P, ICC/IFmore details
Species reactivityReacts with: Human
antigen sequence, corresponding to amino acids 1203-1334 of Human Stabilin 2. (Q8WWQ8)
- Human spleen tissue; U 251 MG cells.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab121893 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.|
FunctionPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
Tissue specificityHighly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
Sequence similaritiesContains 17 EGF-like domains.
Contains 7 FAS1 domains.
Contains 2 laminin EGF-like domains.
Contains 1 Link domain.
DomainRecognizes phosphatidyl serine via its epidermal growth factor-like domains.
Proteolytically processed to yield a 190 kDa protein.
Cellular localizationCell membrane. Cytoplasm. Only a small amount appears to be present at the cell surface.
- Information by UniProt
- 190 kDa form stabilin-2 antibody
- 190 kDa hyaluronan receptor for endocytosis antibody
- EGF-like antibody
ab121893 at 1/200 dilution staining Stabilin 2 in Paraffin-embedded Human Spleen tissue by Immunohistochemistry.
ab128931 at 4 µg/ml staining Stabilin 2 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).
ab121893 has been referenced in 1 publication.
- Danoy M et al. Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment. Biotechnol Bioeng 116:1762-1776 (2019). PubMed: 30883676