Key features and details
- Rabbit polyclonal to Stabilin 2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Stabilin 2 antibody
See all Stabilin 2 primary antibodies
DescriptionRabbit polyclonal to Stabilin 2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human Stabilin 2 aa 1550-1850.
GKVCTLINVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCRGSI YQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDW DKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYI NNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLAT NNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLF NQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRD I
Database link: Q8WWQ8
- IHC-P: Human spleen tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab234858 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/200.|
FunctionPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
Tissue specificityHighly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
Sequence similaritiesContains 17 EGF-like domains.
Contains 7 FAS1 domains.
Contains 2 laminin EGF-like domains.
Contains 1 Link domain.
DomainRecognizes phosphatidyl serine via its epidermal growth factor-like domains.
Proteolytically processed to yield a 190 kDa protein.
Cellular localizationCell membrane. Cytoplasm. Only a small amount appears to be present at the cell surface.
- Information by UniProt
- 190 kDa form stabilin-2 antibody
- 190 kDa hyaluronan receptor for endocytosis antibody
- EGF-like antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab234858 has not yet been referenced specifically in any publications.