Product nameAnti-StAR antibody
See all StAR primary antibodies
DescriptionRabbit polyclonal to StAR
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Predicted to work with: Cow, Dog, Pig
Recombinant protein fragment corresponding to a region within amino acids 15 - 238 of Human StAR (NP_000340).
- 293T, A431, HeLa, HepG2, MOLT4 and Raji cell lysates
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.025% Proclin
Constituents: PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Our Abpromise guarantee covers the use of ab96637 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 32 kDa.|
FunctionPlays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Tissue specificityExpressed in gonads, adrenal cortex and kidney.
PathwaySteroid metabolism; cholesterol metabolism.
Involvement in diseaseDefects in STAR are the cause of adrenal hyperplasia type 1 (AH1) [MIM:201710]. The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
Sequence similaritiesContains 1 START domain.
- Information by UniProt
- Cholesterol trafficker antibody
- Luteinizing hormone induced protein antibody
- mitochondrial antibody
Anti-StAR antibody (ab96637) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg
Predicted band size: 32 kDa
12% SDS PAGE
All lanes : Anti-StAR antibody (ab96637) at 1/1000 dilution
Lane 1 : Whole tissue lysate prepared from murine adrenal gland
Lane 2 : Whole tissue lysate prepared from rat adrenal gland
Lysates/proteins at 50 µg per lane.
All lanes : HRP conjugated goat anti-rabbit polyclonal at 1/2500 dilution
Developed using the ECL technique.
Predicted band size: 32 kDa
Exposure time: 20 seconds
This product has been referenced in:
- Gao X et al. Prenatal exposure to zearalenone disrupts reproductive potential and development via hormone-related genes in male rats. Food Chem Toxicol 116:11-19 (2018). WB . Read more (PubMed: 29627501) »
- Ronis MJ et al. EB 2017 Article: Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis. Exp Biol Med (Maywood) 243:695-707 (2018). Read more (PubMed: 29763383) »