Anti-StARD13 antibody (ab126489)
Key features and details
- Rabbit polyclonal to StARD13
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-StARD13 antibody -
Description
Rabbit polyclonal to StARD13 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence: NPVMLDAPLV SSSLPQPPRD VLNHPFHPKN EKPTRARAKS FLKRMETLRG KGAHGRHKGS GRTGGLVISG PMLQQEPESF KAMQCIQIPN GDLQNSPPPA CRKGLPC, corresponding to amino acids of Human StARD13.
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Positive control
- Human pancreas tissue; U251 MG and Human liver tissue lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab126489 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/250 - 1/500. Predicted molecular weight: 125 kDa.
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IHC-P |
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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WB
1/250 - 1/500. Predicted molecular weight: 125 kDa. |
IHC-P
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. -
Tissue specificity
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. -
Sequence similarities
Contains 1 Rho-GAP domain.
Contains 1 SAM (sterile alpha motif) domain.
Contains 1 START domain. -
Cellular localization
Cytoplasm. Membrane. Mitochondrion membrane. Lipid droplet. - Information by UniProt
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Database links
- Entrez Gene: 90627 Human
- Omim: 609866 Human
- SwissProt: Q9Y3M8 Human
- Unigene: 507704 Human
- Unigene: 721224 Human
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Alternative names
- 46H23.2 antibody
- ARHGAP37 antibody
- Deleted in liver cancer 2 protein antibody
see all
Images
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ab126489 at 1/200 dilution staining StARD13 in paraffin-embedded Human pancreas tissue by Immunohistochemistry.
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All lanes : Anti-StARD13 antibody (ab126489) at 1/250 dilution
Lane 1 : RT4 cell lysate
Lane 2 : U251 MG cell lysate
Lane 3 : Human plasma lysate
Lane 4 : Human liver tissue lysate
Lane 5 : Human tonsil tissue lysate
Developed using the ECL technique.
Predicted band size: 125 kDa
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab126489 has been referenced in 4 publications.
- Wu X et al. miR-182-5p Serves as an Oncogene in Lung Adenocarcinoma through Binding to STARD13. Comput Math Methods Med 2021:7074343 (2021). PubMed: 34335864
- Sun L et al. High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC. Mol Med Rep 19:4881-4889 (2019). PubMed: 31059015
- Yang Z et al. DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway. Oncol Lett 17:2107-2116 (2019). PubMed: 30719106
- Gao F et al. STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells. Onco Targets Ther 11:5371-5381 (2018). PubMed: 30214243