Recombinant
RabMAb

Recombinant Anti-STAT3 (phospho Y705) antibody [EP2147Y] (ab76315)

Rabbit recombinant monoclonal STAT3 (phospho Y705) antibody [EP2147Y]. Validated in WB, IP, IHC, Dot, ICC/IF and tested in Mouse, Rat, Human. Cited in 134 publication(s).

Publishing research using ab76315? Please let us know so that we can cite the reference in this datasheet.

ab76315 has been referenced in 180 publications.

  • Li YM  et al. Alterations of the Immunologic Co-Stimulator B7 and TNFR Families Correlate with Hepatocellular Carcinoma Prognosis and Metastasis by Inactivating STAT3. Int J Mol Sci 20:N/A (2019). PubMed: 30609841
  • Dolatabadi S  et al. JAK-STAT signalling controls cancer stem cell properties including chemotherapy resistance in myxoid liposarcoma. Int J Cancer N/A:N/A (2019). PubMed: 30650179
  • Xu Q  et al. Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis. Toxicology 414:57-67 (2019). PubMed: 30658076
  • Wu R  et al. m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner. Cell Death Dis 10:171 (2019). PubMed: 30787270
  • Ferreras L  et al. Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation. Biochim Biophys Acta Gen Subj 1863:839-848 (2019). PubMed: 30794825
  • Jia Q  et al. Low Levels of Sox2 are required for Melanoma Tumor-Repopulating Cell Dormancy. Theranostics 9:424-435 (2019). PubMed: 30809284
  • Jiang L  et al. Continuous targeted kinase inhibitors treatment induces upregulation of PD-L1 in resistant NSCLC. Sci Rep 9:3705 (2019). PubMed: 30842489
  • Shu F  et al. Stathmin gene silencing suppresses proliferation, migration and invasion of gastric cancer cells via AKT/sCLU and STAT3 signaling. Int J Oncol 54:1086-1098 (2019). PubMed: 30628664
  • Li Z  et al. Low expression of AIM2 combined with high expression of p-STAT3 is associated with poor prognosis in hypopharyngeal squamous cell carcinoma. Oncol Rep 41:2396-2408 (2019). PubMed: 30816544
  • Jiang J  et al. Polydatin inhibits hepatocellular carcinoma via the AKT/STAT3-FOXO1 signaling pathway. Oncol Lett 17:4505-4513 (2019). PubMed: 30944640
  • Ye X  et al. Oncogenic potential of truncated RXRa during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling. Nat Commun 10:1463 (2019). PubMed: 30931933
  • Jiang Y  et al. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evid Based Complement Alternat Med 2019:1908416 (2019). PubMed: 30915142
  • Wang C  et al. Long non-coding RNA MALAT1 regulates angiogenesis following oxygen-glucose deprivation/reoxygenation. J Cell Mol Med 23:2970-2983 (2019). PubMed: 30784209
  • O'Leary OE  et al. The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic. Exp Eye Res 182:144-155 (2019). PubMed: 30876881
  • Luzuriaga J  et al. Human Dental Pulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain. Front Physiol 10:347 (2019). PubMed: 30984027
  • Geletu M  et al. Effect of Caveolin-1 upon Stat3-ptyr705 levels in breast and lung carcinoma cells. Biochem Cell Biol N/A:N/A (2019). PubMed: 30986357
  • Yang L  et al. Interleukin-35 modulates the balance between viral specific CD4+CD25+CD127dim/- regulatory T cells and T helper 17 cells in chronic hepatitis B virus infection. Virol J 16:48 (2019). PubMed: 30992023
  • Sun H  et al. Long noncoding RNA C2dat1 protects H9c2 cells against hypoxia injury by downregulating miR-22. J Cell Physiol N/A:N/A (2019). PubMed: 31004350
  • Xu J  et al. The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1. Hereditas 156:11 (2019). PubMed: 31007650
  • Lei XY  et al. Hepatitis B virus X protein decreases nephrin expression and induces podocyte apoptosis via activating STAT3. Exp Ther Med 17:4223-4229 (2019). PubMed: 31007753
  • Lee JY  et al. YAP-independent mechanotransduction drives breast cancer progression. Nat Commun 10:1848 (2019). PubMed: 31015465
  • Lee EG  et al. Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia. J Immunol Res 2019:5087847 (2019). PubMed: 31073533
  • Pan J  et al. Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy. Biomed Pharmacother 109:1802-1808 (2019). PubMed: 30551434
  • Chen Z  et al. Long non-coding RNA XIST promotes the development of esophageal cancer by sponging miR-494 to regulate CDK6 expression. Biomed Pharmacother 109:2228-2236 (2019). PubMed: 30551480
  • Tan ZB  et al. Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling. J Ethnopharmacol 232:62-72 (2019). PubMed: 30553869
  • Han H  et al. Upregulation of TMEFF2 is involved in the antiproliferative effects of vitamin C and tyrphostin AG490 on GES-1 and AGS cells. Oncol Lett 17:652-659 (2019). PubMed: 30655813
  • Jiang X  et al. BP-1-102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways. Mol Med Rep 19:2698-2706 (2019). PubMed: 30720080
  • Ren W  et al. Oestrogen inhibits PTPRO to prevent the apoptosis of renal podocytes. Exp Ther Med 17:2373-2380 (2019). PubMed: 30783489
  • Kumar G  et al. Targeting STAT3 to Suppress Systemic Pro-Oncogenic Effects from Hepatic Radiofrequency Ablation. Radiology 286:524-536 (2018). PubMed: 28880787
  • Li J  et al. The mTOR kinase inhibitor everolimus synergistically enhances the anti-tumor effect of the Bruton's tyrosine kinase (BTK) inhibitor PLS-123 on Mantle cell lymphoma. Int J Cancer 142:202-213 (2018). PubMed: 28905990
  • Jin Z  et al. TRIM14 promotes colorectal cancer cell migration and invasion through the SPHK1/STAT3 pathway. Cancer Cell Int 18:202 (2018). PubMed: 30555277
  • Yang YZ  et al. Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-ß1/Smad signaling. Acta Pharmacol Sin N/A:N/A (2018). PubMed: 30568253
  • Zhang W  et al. Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer. Transl Oncol 12:485-492 (2018). PubMed: 30594037
  • Akerman AW  et al. Elevated Wall Tension Initiates Interleukin-6 Expression and Abdominal Aortic Dilation. Ann Vasc Surg 46:193-204 (2018). PubMed: 29107003
  • Han CL  et al. LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsy. J Neuroinflammation 15:103 (2018). PubMed: 29636074
  • Balbinot C  et al. The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. J Exp Med 215:911-926 (2018). PubMed: 29439001
  • Zhao Y  et al. Andrographolide attenuates viral myocarditis through interactions with the IL-10/STAT3 and P13K/AKT/NF-?ß signaling pathways. Exp Ther Med 16:2138-2143 (2018). PubMed: 30186451
  • Jiang X  et al. The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2-Mediated Oxidative Stress in the db/db Mouse. Oxid Med Cell Longev 2018:7453865 (2018). PubMed: 30186548
  • Xu NW  et al. Inhibition of JAK2/STAT3 Signaling Pathway Suppresses Proliferation of Burkitt's Lymphoma Raji Cells via Cell Cycle Progression, Apoptosis, and Oxidative Stress by Modulating HSP70. Med Sci Monit 24:6255-6263 (2018). PubMed: 30194286
  • Ke J  et al. Prostaglandin E2 triggers cytochrome P450 17a hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer. Oncol Lett 16:4577-4585 (2018). PubMed: 30214592
  • Nie Y  et al. A novel small inhibitor, LLL12, targets STAT3 in non-small cell lung cancer in vitro and in vivo. Oncol Lett 16:5349-5354 (2018). PubMed: 30250605
  • Kain D  et al. Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction. PLoS One 13:e0203902 (2018). PubMed: 30312306
  • Chen K  et al. Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib. J Neuroinflammation 15:292 (2018). PubMed: 30342528
  • Teratani T  et al. Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis. J Clin Invest 128:1581-1596 (2018). PubMed: 29553485
  • Dong Z  et al. EGFR may participate in immune evasion through regulation of B7-H5 expression in non-small cell lung carcinoma. Mol Med Rep 18:3769-3779 (2018). PubMed: 30106102
  • Ren Z  et al. A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis. Front Immunol 9:2513 (2018). PubMed: 30425719
  • Xiao S & Zhu H Leucine-Rich Alpha-2-Glycoprotein1 Gene Interferes with Regulation of Apoptosis in Leukemia KASUMI-1 Cells. Med Sci Monit 24:8348-8356 (2018). PubMed: 30455412
  • Li M  et al. Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes. Front Pharmacol 9:1180 (2018). PubMed: 30459603
  • Song DG  et al. Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis. Front Pharmacol 9:1337 (2018). PubMed: 30524284
  • Mai D  et al. PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma. Theranostics 8:5213-5230 (2018). PubMed: 30555542
  • Li C  et al. Targeting the RhoA-ROCK pathway to regulate T-cell homeostasis in hypoxia-induced pulmonary arterial hypertension. Pulm Pharmacol Ther 50:111-122 (2018). WB . PubMed: 29673911
  • Xu L  et al. Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels. Mol Oncol 12:269-286 (2018). WB . PubMed: 28865178
  • Li R  et al. Heparin-Poloxamer Thermosensitive Hydrogel Loaded with bFGF and NGF Enhances Peripheral Nerve Regeneration in Diabetic Rats. Biomaterials 168:24-37 (2018). WB . PubMed: 29609091
  • Xu LJ  et al. Combined inhibition of JAK1,2/Stat3-PD-L1 signaling pathway suppresses the immune escape of castration-resistant prostate cancer to NK cells in hypoxia. Mol Med Rep 17:8111-8120 (2018). PubMed: 29693186
  • Wang X  et al. Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway. Cell Death Dis 9:578 (2018). PubMed: 29784961
  • Zhang C  et al. Blocking of the EGFR-STAT3 signaling pathway through afatinib treatment inhibited the intrahepatic cholangiocarcinoma. Exp Ther Med 15:4995-5000 (2018). PubMed: 29805522
  • Zhao L  et al. Long non-coding RNA HULC promotes UVB-induced injury by up-regulation of BNIP3 in keratinocytes. Biomed Pharmacother 104:672-678 (2018). WB ; Human . PubMed: 29803927
  • Zadka L  et al. The expression of IL10RA in colorectal cancer and its correlation with the proliferation index and the clinical stage of the disease. Cytokine 110:116-125 (2018). WB . PubMed: 29730384
  • Ma Y  et al. CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-ß signaling-induced epithelial-mesenchymal transition. Cancer Lett 430:201-214 (2018). PubMed: 29777784
  • Shen M  et al. Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2-mediated STAT3/PI3K/Akt signaling pathway. Int J Mol Med 42:769-778 (2018). PubMed: 29717775
  • Pan H  et al. Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis. Mar Drugs 16:N/A (2018). PubMed: 29874843
  • Shen L  et al. PAG1 promotes the inherent radioresistance of laryngeal cancer cells via activation of STAT3. Exp Cell Res 370:127-136 (2018). PubMed: 29913153
  • Chen K  et al. Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 16:167-178 (2018). PubMed: 29928398
  • Zhang K  et al. The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. J Cell Mol Med 22:3679-3690 (2018). PubMed: 29722127
  • Jurisevic M  et al. The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis. Oncotarget 9:28195-28212 (2018). PubMed: 29963272
  • Bhat AA  et al. Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1. Oncogene N/A:N/A (2018). PubMed: 29991802
  • Kosgodage US  et al. Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Front Pharmacol 9:889 (2018). PubMed: 30150937
  • Douros JD  et al. Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia. Front Endocrinol (Lausanne) 9:465 (2018). PubMed: 30186233
  • Liu Z  et al. Melatonin alleviates adipose inflammation through elevating a-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice. J Pineal Res 64:N/A (2018). PubMed: 29149454
  • Li L  et al. MicroRNA-let-7e regulates the progression and development of allergic rhinitis by targeting suppressor of cytokine signaling 4 and activating Janus kinase 1/signal transducer and activator of transcription 3 pathway. Exp Ther Med 15:3523-3529 (2018). PubMed: 29545878
  • Luo Y  et al. miR-20b negatively regulates VEGF expression by targeting STAT3 in H22 hepatocellular carcinoma cells. Oncol Rep 40:2806-2813 (2018). PubMed: 30132576
  • Cui X  et al. Baicalein represses TGF-ß1-induced fibroblast differentiation through the inhibition of miR-21. Toxicol Appl Pharmacol 358:35-42 (2018). PubMed: 30201452
  • Li Y  et al. The promising antitumour drug disulfiram inhibits viability and induces apoptosis in cardiomyocytes. Biomed Pharmacother 108:1062-1069 (2018). PubMed: 30372806
  • Hua Y  et al. Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino-terminal domain. Pharmacol Res Perspect 6:e00437 (2018). PubMed: 30410767
  • Zhu J  et al. Blueberry, combined with probiotics, alleviates non-alcoholic fatty liver disease via IL-22-mediated JAK1/STAT3/BAX signaling. Food Funct 9:6298-6306 (2018). PubMed: 30411754
  • Wang G  et al. Upregulation of mtSSB by interleukin-6 promotes cell growth through mitochondrial biogenesis-mediated telomerase activation in colorectal cancer. Int J Cancer N/A:N/A (2018). PubMed: 30415472
  • Dai X  et al. Rho GTPase Activating Protein 24 (ARHGAP24) Regulates the Anti-Cancer Activity of Sorafenib Against Breast Cancer MDA-MB-231 Cells via the Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway. Med Sci Monit 24:8669-8677 (2018). PubMed: 30499465
  • Hanna M  et al. Association between physical activity and the expression of mediators of inflammation in normal breast tissue among premenopausal and postmenopausal women. Cytokine 102:151-160 (2018). PubMed: 29102166
  • Chen L  et al. Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway. Oncol Rep 39:1081-1089 (2018). PubMed: 29328487
  • Zhang S  et al. Swiprosin-1 deficiency impairs macrophage immune response of septic mice. JCI Insight 3:N/A (2018). PubMed: 29415882
  • Wang R  et al. Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice. Cell Death Dis 9:352 (2018). PubMed: 29500411
  • Lei Z  et al. PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway. Cell Death Dis 9:375 (2018). PubMed: 29515107
  • Paul S  et al. STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient. Redox Biol 14:423-438 (2018). WB ; Rat . PubMed: 29078168
  • Liu S  et al. Protective effects of N(2)-L-alanyl-L-glutamine mediated by the JAK2/STAT3 signaling pathway on myocardial ischemia reperfusion. Mol Med Rep 17:5102-5108 (2018). PubMed: 29393473
  • Li N  et al. Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. Int J Oncol N/A:N/A (2018). PubMed: 29512698
  • Wang Y  et al. Role of the EZH2/miR-200 axis in STAT3-mediated OSCC invasion. Int J Oncol 52:1149-1164 (2018). PubMed: 29532870
  • Chen L  et al. Effects of purified Omphalia lapidescens protein on metastasis, cell cycle, apoptosis and the JAK-STAT signaling pathway in SGC-7901 human gastric cells. Oncol Lett 15:4161-4170 (2018). PubMed: 29541181
  • Jiang P  et al. Astragaloside IV Prevents Obesity-Associated Hypertension by Improving Pro-Inflammatory Reaction and Leptin Resistance. Mol Cells 41:244-255 (2018). PubMed: 29562733
  • Sun C  et al. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun 9:1241 (2018). PubMed: 29593314
  • Su CY  et al. High density of CD68+ tumor-associated macrophages predicts a poor prognosis in gastric cancer mediated by IL-6 expression. Oncol Lett 15:6217-6224 (2018). PubMed: 29616104
  • Geletu M  et al. Reciprocal regulation of the Cadherin-11/Stat3 axis by caveolin-1 in mouse fibroblasts and lung carcinoma cells. Biochim Biophys Acta 1865:794-802 (2018). WB . PubMed: 29458077
  • Yin L  et al. Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1ß to promote neuronal death. Neurotoxicology 64:195-203 (2018). WB . PubMed: 28385490
  • Attia YM  et al. The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway. Sci Rep 7:12502 (2017). PubMed: 28970500
  • Chernova T  et al. Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf). Curr Biol 27:3302-3314.e6 (2017). PubMed: 29112861
  • Yang L  et al. Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition. Sci Rep 7:7958 (2017). WB ; Human . PubMed: 28801607
  • Huang Y  et al. Gut REG3?-AssociatedLactobacillusInduces Anti-inflammatory Macrophages to Maintain Adipose Tissue Homeostasis. Front Immunol 8:1063 (2017). PubMed: 28928739
  • Chen Y  et al. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug Des Devel Ther 11:2787-2799 (2017). PubMed: 29033541
  • Hanna M  et al. Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients. PLoS One 12:e0183579 (2017). PubMed: 28846716
  • Yu J  et al. Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation. Int J Mol Med 40:1185-1193 (2017). PubMed: 28849106
  • Zhang C  et al. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Exp Ther Med 14:2201-2205 (2017). PubMed: 28962142
  • Yang CH  et al. MicroRNA203a suppresses glioma tumorigenesis through an ATM-dependent interferon response pathway. Oncotarget 8:112980-112991 (2017). PubMed: 29348882
  • Enyu L  et al. The clinical significance and underlying correlation of pStat-3 and integrin avß6 expression in gallbladder cancer. Oncotarget 8:19467-19477 (2017). IHC-P ; Human . PubMed: 28061445
  • Wang D  et al. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 13:4875-4881 (2017). PubMed: 28599489
  • Li X  et al. Negative Regulation of Hepatic Inflammation by the Soluble Resistance-Related Calcium-Binding Protein via Signal Transducer and Activator of Transcription 3. Front Immunol 8:709 (2017). PubMed: 28706517
  • Wang Z  et al. NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription. Cell Mol Life Sci 74:1117-1131 (2017). WB . PubMed: 27783096
  • Yi L  et al. Inflammation-mediated SOD-2 upregulation contributes to epithelial-mesenchymal transition and migration of tumor cells in aflatoxin G1-induced lung adenocarcinoma. Sci Rep 7:7953 (2017). PubMed: 28801561
  • Yu PY  et al. Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. PLoS One 12:e0181885 (2017). PubMed: 28750090
  • Chakraborty D  et al. Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis. Nat Commun 8:1130 (2017). IHC-P . PubMed: 29066712
  • Nguyen A  et al. Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1a axis inhibition. Oncotarget 8:71597-71617 (2017). PubMed: 29069732
  • Li X  et al. Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway. Part Fibre Toxicol 14:53 (2017). IHC . PubMed: 29233151
  • Huang XY  et al. Missing-in-metastasis B (MIM-B) combined with caveolin-1 promotes metastasis of hepatocellular carcinoma. Oncotarget 8:95450-95465 (2017). PubMed: 29221140
  • Jiang X  et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun 8:2099 (2017). PubMed: 29235481
  • Gan L  et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol 8:1507 (2017). PubMed: 29250056
  • Tan HS  et al. KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma. Oncotarget 8:76189-76203 (2017). PubMed: 29100303
  • Shen MJ  et al. Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway. Oncotarget 8:80506-80520 (2017). PubMed: 29113321
  • Wu DP  et al. MiR-1246 Promotes LPS-Induced Inflammatory Injury in Chondrogenic Cells ATDC5 by Targeting HNF4?. Cell Physiol Biochem 43:2010-2021 (2017). PubMed: 29055957
  • Contreras C  et al. Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity. Diabetes 66:87-99 (2017). PubMed: 27634226
  • Cochrane A  et al. Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis. Stem Cells 35:952-966 (2017). PubMed: 28207177
  • Ye W  et al. GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways. Oncotarget 8:87002-87015 (2017). PubMed: 29152059
  • Xu Z  et al. LARP1 is regulated by the XIST/miR-374a axis and functions as an oncogene in non-small cell lung carcinoma. Oncol Rep 38:3659-3667 (2017). PubMed: 29039571
  • Cao WJ  et al. Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by Janus kinase 2 inhibition in leukemia cells. Mol Med Rep 13:3297-302 (2016). PubMed: 26934953
  • Xiao B  et al. TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation. Molecules 21:N/A (2016). PubMed: 27834930
  • Chi HC  et al. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy 12:2271-2285 (2016). PubMed: 27653365
  • Zhang ZM  et al. Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2-STAT3 signaling pathway. Mol Med Rep 13:3684-90 (2016). PubMed: 26936086
  • Lu YM  et al. Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway. Mol Med Rep 13:2235-40 (2016). PubMed: 26795301
  • Wang Y  et al. Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice. Mol Med Rep 14:3293-300 (2016). PubMed: 27573470
  • Jiang CY  et al. LIM domain only 2 over-expression in prostate stromal cells facilitates prostate cancer progression through paracrine of Interleukin-11. Oncotarget 7:26247-58 (2016). PubMed: 27028859
  • Kong X  et al. Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma. Oncotarget 7:29465-79 (2016). PubMed: 27102295
  • Fan Z  et al. MiR-125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression. Oncogenesis 5:e197 (2016). PubMed: 26878391
  • Yang C  et al. Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway. Lab Invest 96:950-8 (2016). PubMed: 27322953
  • Ball DP  et al. Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent. Oncotarget 7:20669-79 (2016). WB . PubMed: 26942696
  • Luo LN  et al. Osthole decreases renal ischemia-reperfusion injury by suppressing JAK2/STAT3 signaling activation. Exp Ther Med 12:2009-2014 (2016). WB ; Rat . PubMed: 27698686
  • Kling T  et al. Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma. EBioMedicine 12:72-85 (2016). WB . PubMed: 27667176
  • Liu Z  et al. Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo. Am J Transl Res 8:1319-38 (2016). PubMed: 27186262
  • Zhu L  et al. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35:5388-5399 (2016). WB ; Human . PubMed: 27109105
  • Xue H  et al. A Novel Tumor-promoting Mechanism of IL6 and the Therapeutic Efficacy of Tocilizumab: Hypoxia-induced IL6 Is a Potent Autophagy Initiator in Glioblastoma via the p-STAT3-MIR155-3p-CREBRF Pathway. Autophagy N/A:0 (2016). WB ; Human . PubMed: 27163161
  • Liu F  et al. Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy. Sci Rep 6:33676 (2016). WB . PubMed: 27633396
  • Zheng H  et al. TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling. Sci Rep 6:37070 (2016). WB ; Human . PubMed: 27901021
  • Peng HY  et al. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. PLoS One 11:e0158440 (2016). WB ; Human . PubMed: 27367272
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