Anti-STAT5 antibody (ab126832)

Rabbit polyclonal STAT5 antibody. Validated in WB and tested in Human. Cited in 1 publication(s). Immunogen corresponding to synthetic peptide.

Overview

  • Product name

  • Description

    Rabbit polyclonal to STAT5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    DGYVK

    , corresponding to amino acids 692-696 of Human STAT5 (UniProt P42229).

  • Positive control

    • Human recombinant STAT5 protein; K562 cell lysate.
  • General notes

    For storage at 4°C for several months add 0.1% NaN3.

Properties

Applications

Our Abpromise guarantee covers the use of ab126832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 91 kDa.

Target

  • Function

    Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
  • Sequence similarities

    Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • Post-translational
    modifications

    Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.
  • Cellular localization

    Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
  • Information by UniProt
  • Database links

  • Alternative names

    • MGF antibody
    • Signal transducer and activator of transcription 5A antibody
    • Signal Transducer and Activator of Transcription 5B antibody
    • STA5A_HUMAN antibody
    • STAT 5A antibody
    • STAT 5B antibody
    • STAT5 antibody
    • STAT5A antibody
    • STAT5B antibody
    • Transcription factor STAT5A antibody
    • Transcription factor STAT5B antibody
    see all

Images

  • All lanes : Anti-STAT5 antibody (ab126832) at 1/1000 dilution

    Lane 1 : Human recombinant STAT1 beta
    Lane 2 : Human recombinant STAT2
    Lane 3 : Human recombinant STAT3
    Lane 4 : Human recombinant STAT4
    Lane 5 : Human recombinant STAT5
    Lane 6 : Human recombinant STAT6

    Lysates/proteins at 0.005 µg per lane.

    Predicted band size: 91 kDa

  • All lanes : Anti-STAT5 antibody (ab126832) at 1/1000 dilution

    Lane 1 : K562 cell lysate at 3 µg
    Lane 2 : K562 cell lysate at 10 µg
    Lane 3 : K562 cell lysate at 30 µg

    Predicted band size: 91 kDa

References

This product has been referenced in:

  • Ma H  et al. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. J Immunol Res 2018:6985031 (2018). Read more (PubMed: 30013992) »
See 1 Publication for this product

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