Key features and details
- Rabbit polyclonal to Staufen/STAU1
- Suitable for: ICC/IF, WB, ICC
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Staufen/STAU1 antibody
See all Staufen/STAU1 primary antibodies
DescriptionRabbit polyclonal to Staufen/STAU1
At least three isoforms of Staufen/STAU1 are known to exist; ab105398 will detect all three.
Tested applicationsSuitable for: ICC/IF, WB, ICCmore details
Species reactivityReacts with: Mouse, Rat, Human
- Rat brain tissue lysate.
This product was previously labelled as Staufen
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab105398 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 20 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 63 kDa.|
|ICC||Use a concentration of 10 µg/ml.|
FunctionBinds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
Tissue specificityWidely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
Sequence similaritiesContains 3 DRBM (double-stranded RNA-binding) domains.
DomainOne of the DRDB could be involved in RER binding.
The C-terminal contains the tubulin binding domain (TBD).
Cellular localizationCytoplasm. Rough endoplasmic reticulum. Localizes exclusively with the rough reticulum endoplasmic.
- Information by UniProt
- Double stranded RNA binding protein Staufen homolog 1 antibody
- Double stranded RNA binding protein Staufen homolog antibody
- Double-stranded RNA-binding protein Staufen homolog 1 antibody
Lane 1 : Anti-Staufen/STAU1 antibody (ab105398) at 1 µg/ml
Lane 2 : Anti-Staufen/STAU1 antibody (ab105398) at 2 µg/ml
All lanes : Rat brain tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 63 kDa
Immunohistochemistry of Staufen/STAU1 in Human brain tissue with ab105398 at 10 µg/ml.
Immunofluorescence of STAU1 in Human Brain cells using ab105398 at 20 ug/ml.
ab105398 has been referenced in 1 publication.
- Ricci EP et al. Staufen1 senses overall transcript secondary structure to regulate translation. Nat Struct Mol Biol 21:26-35 (2014). PubMed: 24336223