Overview

  • Product name

    Anti-Staufen/STAU1 antibody
    See all Staufen/STAU1 primary antibodies
  • Description

    Rabbit polyclonal to Staufen/STAU1
  • Host species

    Rabbit
  • Specificity

    At least three isoforms of Staufen/STAU1 are known to exist; ab105398 will detect all three.

  • Tested applications

    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Staufen/STAU1 (C terminal).
    Database link: NP_059347
    (Peptide available as ab110446)

  • Positive control

    • Rat brain tissue lysate.
  • General notes

     This product was previously labelled as Staufen

     

Properties

Applications

Our Abpromise guarantee covers the use of ab105398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 63 kDa.
ICC Use a concentration of 10 µg/ml.

Target

  • Function

    Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
  • Tissue specificity

    Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
  • Sequence similarities

    Contains 3 DRBM (double-stranded RNA-binding) domains.
  • Domain

    One of the DRDB could be involved in RER binding.
    The C-terminal contains the tubulin binding domain (TBD).
  • Cellular localization

    Cytoplasm. Rough endoplasmic reticulum. Localizes exclusively with the rough reticulum endoplasmic.
  • Information by UniProt
  • Database links

  • Alternative names

    • Double stranded RNA binding protein Staufen homolog 1 antibody
    • Double stranded RNA binding protein Staufen homolog antibody
    • Double-stranded RNA-binding protein Staufen homolog 1 antibody
    • FLJ25010 antibody
    • MGC124588 antibody
    • PPP1R150 antibody
    • STAU antibody
    • STAU1 antibody
    • STAU1_HUMAN antibody
    • staufen antibody
    • Staufen RNA binding protein (Drosophila) antibody
    • Staufen RNA binding protein homolog 1 antibody
    • Staufen, Drosophila, homolog of, 1 antibody
    • Staufen, RNA binding protein, homolog 1 (Drosophila) antibody
    • staufen-like antibody
    see all

Images

  • Lane 1 : Anti-Staufen/STAU1 antibody (ab105398) at 1 µg/ml
    Lane 2 : Anti-Staufen/STAU1 antibody (ab105398) at 2 µg/ml

    All lanes : Rat brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 63 kDa

  • Immunohistochemistry of Staufen/STAU1 in Human brain tissue with ab105398 at 10 µg/ml.

  • Immunofluorescence of STAU1 in Human Brain cells using ab105398 at 20 ug/ml.

References

This product has been referenced in:

  • Ricci EP  et al. Staufen1 senses overall transcript secondary structure to regulate translation. Nat Struct Mol Biol 21:26-35 (2014). Read more (PubMed: 24336223) »
See 1 Publication for this product

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