Overview

  • Product name

    Anti-STEAP4 antibody - N-terminal
    See all STEAP4 primary antibodies
  • Description

    Rabbit polyclonal to STEAP4 - N-terminal
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Horse, Monkey, Gorilla, Common marmoset, Bat
  • Immunogen

    Synthetic 15 amino acid peptide from the N terminal region of Human STEAP4.

  • Positive control

    • Human pancreas tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab140951 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
  • Tissue specificity

    Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.
  • Sequence similarities

    Belongs to the STEAP family.
    Contains 1 ferric oxidoreductase domain.
  • Cellular localization

    Cell membrane. Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • alpha-induced protein 9 antibody
    • Metalloreductase STEAP4 antibody
    • six transmembrane prostate protein 2 antibody
    • Six-transmembrane epithelial antigen of prostate 4 antibody
    • SixTransMembrane protein of prostate 2 antibody
    • STAMP 2 antibody
    • STAMP2 antibody
    • STEA4_HUMAN antibody
    • STEAP 4 antibody
    • STEAP family member 4 antibody
    • STEAP4 antibody
    • TIARP antibody
    • TNFAIP 9 antibody
    • TNFAIP9 antibody
    • Tumor necrosis factor antibody
    • tumor necrosis factor, alpha-induced protein 9 antibody
    • tumor necrosis-alpha-induced adipose-related protein antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue labelling STEAP4 with ab140951 at 2.5 µg/ml after heat-induced antigen retrieval.

References

ab140951 has not yet been referenced specifically in any publications.

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