Key features and details
- Rabbit polyclonal to Steroid sulfatase
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Steroid sulfatase antibody
See all Steroid sulfatase primary antibodies
DescriptionRabbit polyclonal to Steroid sulfatase
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rat, Horse, Guinea pig, Cow
- WB: Placental cell lysate
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab62219 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 5 µg/ml. Detects a band of approximately 64 kDa (predicted molecular weight: 64 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
FunctionConversion of sulfated steroid precursors to estrogens during pregnancy.
Involvement in diseaseDefects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.
Sequence similaritiesBelongs to the sulfatase family.
modificationsThe conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
- ARSC antibody
- ARSC1 antibody
- Arylsulfatase C antibody
ab62219 has been referenced in 3 publications.
- Lee WM et al. The Role of Steroid Sulfatase as a Prognostic Factor in Patients with Endometrial Cancer. Yonsei Med J 57:754-60 (2016). IHC-P . PubMed: 26996578
- Jiang M et al. Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms. J Biol Chem 289:8086-97 (2014). WB ; Mouse . PubMed: 24497646
- Fu XS & Li PP Shu-Gan-Liang-Xue Decoction Simultaneously Down-regulates Expressions of Aromatase and Steroid Sulfatase in Estrogen Receptor Positive Breast Cancer Cells. Chin J Cancer Res 23:208-13 (2011). PubMed: 23467843