• Product name

    Anti-Steroidogenic Factor 1/SF-1 antibody [EPR11695(B)]
    See all Steroidogenic Factor 1/SF-1 primary antibodies
  • Description

    Rabbit monoclonal [EPR11695(B)] to Steroidogenic Factor 1/SF-1
  • Host species

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Steroidogenic Factor 1/SF-1.
    Database link: Q13285

  • Positive control

    • Jurkat and HepG2 whole cell lysate (ab7900).
  • General notes

    Previously labelled as Steroidogenic Factor 1.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab168380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 52 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3.
    • Involvement in disease

      Defects in NR5A1 are a cause of 46,XY disorder of sex development (46,XY DSD) [MIM:612965]; also known as XY sex reversal with or without adrenal failure. A congenital condition in which development of chromosomal, gonadal, or antomic sex is atypical. 46,XY DSD is a disorder of gonadal (testicular) development, which may be complete or partial. The complete form includes streak gonads, normal mullerian structures, and normal female external genitalia. The partial form includes ambiguous external genitalia and partial development of mullerian and wolffian structures.
      Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect (ACIWOD) [MIM:184757]. ACIWOD is characterized by severe 'slackness' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.
      Defects in NR5A1 are the cause of premature ovarian failure type 7 (POF7) [MIM:612964]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
    • Sequence similarities

      Belongs to the nuclear hormone receptor family. NR5 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Post-translational

      Acetylation stimulates the transcriptional activity.
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • AD4BP antibody
      • Adrenal 4 binding protein antibody
      • Adrenal 4-binding protein antibody
      • ELP antibody
      • FTZ 1 antibody
      • FTZ1 antibody
      • FTZF 1 antibody
      • FTZF1 antibody
      • Fushi tarazu factor (Drosophila) homolog 1 antibody
      • Fushi tarazu factor homolog 1 antibody
      • hSF 1 antibody
      • NR5A1 antibody
      • Nuclear receptor AdBP4 antibody
      • Nuclear receptor subfamily 5 group A member 1 antibody
      • POF7 antibody
      • SF 1 antibody
      • SF-1 antibody
      • SF1 antibody
      • SPGF8 antibody
      • SRXY3 antibody
      • Steroid hormone receptor Ad4BP antibody
      • Steroidogenic factor 1 antibody
      • Steroidogenic factor 1 nuclear receptor antibody
      • STF 1 antibody
      • STF-1 antibody
      • STF1 antibody
      • STF1_HUMAN antibody
      see all


    • All lanes : Anti-Steroidogenic Factor 1/SF-1 antibody [EPR11695(B)] (ab168380) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : HepG2 cell lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 52 kDa


    This product has been referenced in:

    • Medwid S  et al. Prenatal exposure to bisphenol A disrupts adrenal steroidogenesis in adult mouse offspring. Environ Toxicol Pharmacol 43:203-8 (2016). WB ; Mouse . Read more (PubMed: 27017381) »
    See 1 Publication for this product

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