Overview

  • Product name

    Anti-Sterol carrier protein 2 antibody
    See all Sterol carrier protein 2 primary antibodies
  • Description

    Rabbit polyclonal to Sterol carrier protein 2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Sterol carrier protein 2 aa 1-322.
    Database link: P22307

  • Positive control

    • WB: A2780 whole cell lysate. IHC-P: Human placenta tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab235605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 59 kDa.

Target

  • Function

    Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
  • Tissue specificity

    Liver, fibroblasts, and placenta.
  • Involvement in disease

    Defects in SCP2 are a cause of leukoencephalopathy with dystonia and motor neuropathy (LDMN) [MIM:613724]; also known as sterol carrier protein 2 deficiency. LDMN is a syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine.
  • Sequence similarities

    In the N-terminal section; belongs to the thiolase family.
    Contains 1 SCP2 domain.
  • Cellular localization

    Mitochondrion; Cytoplasm. Mitochondrion. Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues and Peroxisome. Interaction with PEX5 is essential for peroxisomal import.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp686C12188 antibody
    • DKFZp686D11188 antibody
    • NLTP antibody
    • NLTP_HUMAN antibody
    • Non-specific lipid-transfer protein antibody
    • Nonspecific lipid transfer protein antibody
    • NSL TP antibody
    • NSL-TP antibody
    • OTTHUMP00000010488 antibody
    • OTTHUMP00000231766 antibody
    • OTTHUMP00000231767 antibody
    • OTTHUMP00000231768 antibody
    • OTTHUMP00000231769 antibody
    • OTTHUMP00000231770 antibody
    • OTTHUMP00000231772 antibody
    • OTTHUMP00000231773 antibody
    • OTTHUMP00000231774 antibody
    • OTTHUMP00000231776 antibody
    • OTTHUMP00000234662 antibody
    • Propanoyl CoA C acyltransferase antibody
    • Propanoyl-CoA C-acyltransferase antibody
    • SCP 2 antibody
    • SCP chi antibody
    • SCP X antibody
    • SCP-2 antibody
    • SCP-chi antibody
    • SCP-X antibody
    • SCP2 antibody
    • SCPchi antibody
    • SCPX antibody
    • Sterol carrier protein 2 antibody
    • Sterol carrier protein X antibody
    see all

Images

  • Anti-Sterol carrier protein 2 antibody (ab235605) at 1/500 dilution + A2780 (human ovarian cancer cell line) whole cell lysate

    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 59 kDa

  • Paraffin-embedded human placenta tissue stained for Sterol carrier protein 2 using ab235605 at 1/100 dilution in immunohistochemical analysis.

References

ab235605 has not yet been referenced specifically in any publications.

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