Overview

  • Product name

    STF-083010, IRE1alpha endonuclease inhibitor
  • Description

    Selective IRE1α endonuclease inhibitor
  • Biological description

    Selective IRE1α endonuclease inhibitor. Dose dependently inhibits XBP-1 splicing. Shows cancer cell selective cytotoxic and cytostatic antiproliferative effects. Shows antitumor effects in vivo.
  • CAS Number

    307543-71-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(Z)-(2-Oxonaphthalen-1-ylidene)methyl]thiophene-2-sulfonamide
  • Molecular weight

    317.38
  • Molecular formula

    C15H11NO3S2
  • PubChem identifier

    6537512
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C\2C(=C1)C=CC(=O)/C2=C\NS(=O)(=O)C3=CC=CS3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chien W  et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget 5:4881-94 (2014). Read more (PubMed: 24952679) »
  • Tam AB  et al. Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD. Cell Rep 9:850-8 (2014). Read more (PubMed: 25437541) »
  • Papandreou I  et al. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117:1311-4 (2011). Read more (PubMed: 21081713) »

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