Overview

  • Product name

    Anti-STIM2 antibody - N-terminal
    See all STIM2 primary antibodies
  • Description

    Sheep polyclonal to STIM2 - N-terminal
  • Host species

    Sheep
  • Specificity

    BLAST analysis suggests cross-reactivity with mouse based on 100% sequence homology.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human STIM2 (N terminal).
    Database link: Q9P246

  • Positive control

    • Human kidney tissue.
  • General notes

    Centrifuge product before removing cap. Only dilute immediately prior to use.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.20
    Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab219646 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
  • Tissue specificity

    Expressed in all tissues and tumor cell lines examined.
  • Sequence similarities

    Contains 1 EF-hand domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Post-translational
    modifications

    Glycosylated.
    Phosphorylated predominantly on Ser residues.
  • Cellular localization

    Endoplasmic reticulum membrane. Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ39527 antibody
    • KIAA1482 antibody
    • STIM 2 antibody
    • STIM2 antibody
    • STIM2_HUMAN antibody
    • Stromal interaction molecule 2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling STIM2 with ab219646 at 5 µg/ml.

References

ab219646 has not yet been referenced specifically in any publications.

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