Key features and details
- Sheep polyclonal to STIM2 - N-terminal
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-STIM2 antibody - N-terminal
See all STIM2 primary antibodies
DescriptionSheep polyclonal to STIM2 - N-terminal
SpecificityBLAST analysis suggests cross-reactivity with mouse based on 100% sequence homology.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic peptide corresponding to Human STIM2 (N terminal).
Database link: Q9P246
- Human kidney tissue.
Centrifuge product before removing cap. Only dilute immediately prior to use.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab219646 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 5 µg/ml.|
FunctionFunctions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
Tissue specificityExpressed in all tissues and tumor cell lines examined.
Sequence similaritiesContains 1 EF-hand domain.
Contains 1 SAM (sterile alpha motif) domain.
Phosphorylated predominantly on Ser residues.
Cellular localizationEndoplasmic reticulum membrane. Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
- Information by UniProt
- FLJ39527 antibody
- KIAA1482 antibody
- STIM 2 antibody
ab219646 has not yet been referenced specifically in any publications.