Overview

  • Product name

    STO-609 acetate, CaM-KK inhibitor
  • Description

    Potent, competitive, selective and cell-permeable inhibitor of CaM-KK
  • Biological description

    Potent, competitive, selective and cell-permeable inhibitor of CaM-KK (Ki values are0.21 µM and 40 nM for CaM-KKα and CaM-KKβ respectively). Potent, competitive AhR agonist (EC50 = 43 nM). Active in vivo.
  • Purity

    > 98%
  • CAS Number

    52029-86-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Anderson KA  et al. Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab 7:377-88 (2008). Read more (PubMed: 18460329) »
  • Monteiro P  et al. Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). Drug Metab Dispos 36:2556-63 (2008). Read more (PubMed: 18755850) »
  • Tokumitsu H  et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem 277:15813-8 (2002). Read more (PubMed: 11867640) »

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