Anti-STOX1 antibody - C-terminal (ab189436)
- Datasheet
- References
- Protocols
Overview
-
Product name
Anti-STOX1 antibody - C-terminal
See all STOX1 primary antibodies -
Description
Rabbit polyclonal to STOX1 - C-terminal -
Host species
Rabbit -
Specificity
At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. ab189436 will recognize the longest isoform. -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human STOX1 (C terminal). Raised against a 14 amino acid peptide near the C-terminal end.
Database link: Q6ZVD7 -
Positive control
- Human liver lysate. Human adrenal or skeletal muscle tissue.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at 4°C (up to 6 months). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
Our Abpromise guarantee covers the use of ab189436 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. | |
| WB | Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 111 kDa. |
Target
-
Involvement in disease
Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4) [MIM:609404]; also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. The pathological mechanism of PEE4 involves the loss of function of STOX1 in the placenta. -
Cellular localization
Nucleus; Nucleus > nucleolus and Cytoplasm. Nucleus. Either found in the cytoplasm or in the nucleus. Nuclear expression of isoform A seems to be restricted to polyploid trophoblast cells. - Information by UniProt
-
Database links
- Entrez Gene: 219736 Human
- Omim: 609397 Human
- SwissProt: Q6ZVD7 Human
- Unigene: 37636 Human
-
Alternative names
- C10orf24 antibody
- chromosome 10 open reading frame 241 antibody
- PEE4 antibody
see all
Images
-
Western blot - Anti-STOX1 antibody - C-terminal (ab189436)All lanes : Anti-STOX1 antibody - C-terminal (ab189436) at 1 µg/ml
Lane 1 : Human liver lysate
Lane 2 : Human liver lysate plus blocking peptide
Predicted band size: 111 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody - C-terminal (ab189436)Immunohistochemical analysis of formalin fixed, paraffin embedded human skeletal muscle labeling STOX1 with ab189436 at 5 μg/ml.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody - C-terminal (ab189436)Immunohistochemical analysis of formalin fixed, paraffin embedded human adrenal tissue labeling STOX1 with ab189436 at 5 μg/ml.
Datasheets and documents
References
ab189436 has not yet been referenced specifically in any publications.
