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    stra6-antibody-ab238329.pdf

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Stem Cells Lineage Markers Endoderm
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Anti-Stra6 antibody (ab238329)

  • Datasheet
  • SDS
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Immunocytochemistry/ Immunofluorescence - Anti-Stra6 antibody (ab238329)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stra6 antibody (ab238329)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stra6 antibody (ab238329)

Key features and details

  • Rabbit polyclonal to Stra6
  • Suitable for: IHC-P, ICC/IF
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human Stra6 protein (ab163804)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Stra6 antibody
    See all Stra6 primary antibodies
  • Description

    Rabbit polyclonal to Stra6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Stra6 aa 530-667.
    Database link: Q9BX79

  • Positive control

    • IHC-P: Human kidney and placenta tissue. ICC/IF: A549 cells.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Constituents: 50% Glycerol (glycerin, glycerine), PBS, 0.03% Proclin 300
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purity >95%
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Stem Cells
    • Lineage Markers
    • Endoderm
    • Signal Transduction
    • Metabolism
    • Vitamins / Minerals
    • Developmental Biology
    • Lineage specification
    • Endoderm
    • Metabolism
    • Pathways and Processes
    • Cofactors, Vitamins / minerals
    • Vitamins / minerals

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Stra6 protein (ab163804)

Applications

Our Abpromise guarantee covers the use of ab238329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500.
ICC/IF 1/50 - 1/200.

Target

  • Function

    May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex.
  • Tissue specificity

    Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.
  • Involvement in disease

    Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9) [MIM:601186]; also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia.
    Note=Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession Q9BX79 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 64220 Human
    • Omim: 610745 Human
    • SwissProt: Q9BX79 Human
    • Unigene: 24553 Human
    • Alternative names

      • MCOPCB8 antibody
      • MCOPS9 antibody
      • PP14296 antibody
      • Stimulated by retinoic acid 6 homolog antibody
      • Stimulated by retinoic acid gene 6 protein homolog antibody
      • STRA6 antibody
      • STRA6_HUMAN antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-Stra6 antibody (ab238329)
      Immunocytochemistry/ Immunofluorescence - Anti-Stra6 antibody (ab238329)

      A549 (human lung carcinoma cell line) cells stained for Stra6 using ab238329 at a dilution of 1/100 in ICC/IF.

      The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. The cells were then incubated with the primary antibody overnight at 4°C. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L). Counterstained with DAPI.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stra6 antibody (ab238329)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stra6 antibody (ab238329)

      Paraffin-embedded human placneta tissue stained for Stra6 with ab238329 at a 1/300 dilution in immunohistochemical analysis.

      After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stra6 antibody (ab238329)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stra6 antibody (ab238329)

      Paraffin-embedded human kidney tissue stained for Stra6 with ab238329 at a 1/300 dilution in immunohistochemical analysis.

      After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab238329? Please let us know so that we can cite the reference in this datasheet.

    ab238329 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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