Overview

  • Product name

  • Description

    Goat polyclonal to Stra6
  • Host species

    Goat
  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    QAFRKAALTSAKAN

    , corresponding to C terminal amino acids 653-665 of mouse (NP_033317.1) and rat (NP_001025095.1) Stra6

  • Positive control

    • Rat brain lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab77616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 74 kDa).

Please note a non-specific band of ~80kDa.

ELISA Use at an assay dependent concentration.

Target

  • Function

    May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex.
  • Tissue specificity

    Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.
  • Involvement in disease

    Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9) [MIM:601186]; also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia.
    Note=Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • MCOPCB8 antibody
    • MCOPS9 antibody
    • PP14296 antibody
    • Stimulated by retinoic acid 6 homolog antibody
    • Stimulated by retinoic acid gene 6 protein homolog antibody
    • STRA6 antibody
    • STRA6_HUMAN antibody
    see all

Images

  • Anti-Stra6 antibody (ab77616) at 0.3 µg/ml + rat brain lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 74 kDa
    Observed band size: 85 kDa
    why is the actual band size different from the predicted?


    Exposure time: 1 hour

References

ab77616 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab77616.
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