Overview

  • Product name

  • Description

    Rabbit polyclonal to STRAD
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human STRAD aa 25-210.
    Database link: Q7RTN6

  • Positive control

    • IHC-P: Human brain and kidney tissue.
  • General notes

     This product was previously labelled as LYK5

     

Properties

Applications

Our Abpromise guarantee covers the use of ab230113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Relevance

    Members of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.
  • Cellular localization

    Cytoplasmic and Nuclear
  • Database links

  • Alternative names

    • Protein kinase LYK5 antibody
    • Serologically defined breast cancer antigen NY BR 96 antibody
    • STE20 related adapter protein antibody
    • STRAD alpha antibody
    • STRAD antibody
    see all

Images

  • Paraffin-embedded human brain tissue stained for STRAD with ab230113 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human kidney tissue stained for STRAD with ab230113 at 1/100 dilution in immunohistochemical analysis.

References

ab230113 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab230113.
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