Anti-sTRAIL Receptor 2 antibody [DR5-01-1] (Allophycocyanin) (ab243080)

Overview

  • Product name

    Anti-sTRAIL Receptor 2 antibody [DR5-01-1] (Allophycocyanin)
  • Description

    Mouse monoclonal [DR5-01-1] to sTRAIL Receptor 2 (Allophycocyanin)
  • Host species

    Mouse
  • Conjugation

    Allophycocyanin. Ex: 645nm, Em: 660nm
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human sTRAIL Receptor 2. Human IgG heavy chain and extracellular domain of sTRAIL Receptor 2 .
    Database link: O14763

  • Positive control

    • Flow Cyt: sTRAIL Receptor 2-transfectants.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C. Store In the Dark.
  • Storage buffer

    Preservative: 0.0975% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Size exclusion
  • Purification notes

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
  • Clonality

    Monoclonal
  • Clone number

    DR5-01-1
  • Isotype

    IgG1
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab243080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use a concentration of 2 µg/ml.

Target

  • Function

    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
  • Tissue specificity

    Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
  • Involvement in disease

    Squamous cell carcinoma of the head and neck
  • Sequence similarities

    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Apoptosis inducing protein TRICK2A 2B antibody
    • Apoptosis inducing protein TRICK2A/2B antibody
    • Apoptosis inducing receptor TRAIL R2 antibody
    • CD262 antibody
    • CD262 antigen antibody
    • Cytotoxic TRAIL receptor 2 antibody
    • Death domain containing receptor for TRAIL Apo 2L antibody
    • Death receptor 5 antibody
    • DR5 antibody
    • Fas like protein antibody
    • Killer antibody
    • Killer DR5 antibody
    • KILLER/DR5 antibody
    • p53 regulated DNA damage inducible cell death receptor killer antibody
    • p53 regulated DNA damage inducible cell death receptor(killer) antibody
    • TNF receptor superfamily member 10b antibody
    • TNF related apoptosis inducing ligand receptor 2 antibody
    • TNF-related apoptosis-inducing ligand receptor 2 antibody
    • TNFRSF10B antibody
    • TR10B_HUMAN antibody
    • Trail R2 antibody
    • TRAIL receptor 2 antibody
    • TRAIL-R2 antibody
    • TRAILR2 antibody
    • TRICK2 antibody
    • TRICK2A antibody
    • TRICK2B antibody
    • TRICKB antibody
    • Tumor necrosis factor receptor like protein ZTNFR9 antibody
    • Tumor necrosis factor receptor superfamily member 10B antibody
    • Tumor necrosis factor receptor superfamily, member 10b antibody
    • ZTNFR9 antibody
    see all

Images

  • Flow Cytometry analysis of sTRAIL Receptor 2 transfectants labeling sTRAIL Receptor 2 with ab243080 at 2 μg/ml. Surface staining.

References

ab243080 has not yet been referenced specifically in any publications.

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