Product nameStreptomycin sulfate (aqueous), aminoglycoside antibiotic
- Streptomycin Sulphate
Aminoglycoside antibiotic. Highly active against gram-negative bacteria with some activity against gram-positive bacteria. Often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. Acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSupplied in water (30 mg/ml)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Sharma D et al. Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol 374:1065-76 (2007). Read more (PubMed: 17967466) »
- Luzzatto L et al. Mechanism of action of streptomycin in E. coli: interruption of the ribosome cycle at the initiation of protein synthesis. Proc Natl Acad Sci U S A 60:873-80 (1968). Read more (PubMed: 4875806) »